Total O 100 18 combined ith Hb 14 a 10〓 40 Dissolved O2-- 2 0 20 40 60 80 100600 PO2(mmHg)
Hypoxia Introduction Classification, etiology and pathogenesis Functional and metabolic changes Factors involved in tolerance to hypoxia Oxygen treatment and oxygen toxicity
Hypoxia Introduction Classification, etiology and pathogenesis Functional and metabolic changes Factors involved in tolerance to hypoxia Oxygen treatment and oxygen toxicity
Classification External Gas transport Tissue Air respiration +Hb circulation cels 低张性缺氧血漩性缺氧「循环性缺氧「组织性缺氧 Hypotonic Hemic Circulatory Histogenous poria poria ypOXIa ypoxia
Air Gas transport +Hb circulation Tissue cells External respiration Classification 血液性缺氧 Hemic hypoxia 循环性缺氧 Circulatory hypoxia 低张性缺氧 Hypotonic hypoxia 组织性缺氧 Histogenous hypoxia
循环性缺氧 低张性缺氧 Circulatory组织性缺氧 Hypotonic ○ hypoxia Histogenous yeola 血液性缺氧 hypoxia Hemic h ypoⅹa
低张性缺氧 Hypotonic hypoxia 血液性缺氧 Hemic hypoxia 循环性缺氧 Circulatory hypoxia 组织性缺氧 Histogenous hypoxia
1. Hypotonic hypoxia -PaO2l Causes 1)PiO2: high altitude(3000-4000m) 海拔高度大气压 PiO2 PAO2 SO2 (mmHg(mmHg) mm 海平面 760 159 105 95 1000 680 140 90 94 2000 600 125 70 92 3000 530 110 62 5000 405 85 45 75 6000 366 40 70 8000 270 56 30 50
1. Hypotonic hypoxia — PaO2↓ Causes : 1) PiO2↓: high altitude (3000~4000m) 海拔高度 大气压 PiO2 PAO2 SO2 (m) (mmHg) (mmHg) (mmHg) % 海平面 760 159 105 95 1000 680 140 90 94 2000 600 125 70 92 3000 530 110 62 90 5000 405 85 45 75 6000 366 74 40 70 8000 270 56 30 50