rmezrmembrane space Matra NA Der membrane Cristae Inner membrane ATP synthase particles
Intermembrane space Ribosome Matrix DNA Outer membrane Cristae Inner membrane ATP synthase particles (
3)Online about mitochondrial functions and bioactivities Cellular aerobic respiration--oxidation metabolism oxidation of pyruvate, fatty acids and amino acids TCA and electron transport (ET)--establishment of a proton -motive force and the atP formation Transport across mitochondrial (inner ) membrane Active cotransport: H/Pyruvate(symport), ATP/ADP (antiport), Pi/H (symport)etc Enzymatic shuttle-transports: glycerol phosphate shuttle malate-aspartate shuttle, fatty acyl-carnitine transport Other activities relaying on energized membrane Pull calcium into Mit Importing of specifically-targeted polypeptides to the mit matrix from the cytosol
3) Online about mitochondrial functions and bioactivities *Cellular aerobic respiration--oxidation metabolism: oxidation of pyruvate, fatty acids and amino acids;TCA and electron transport (ET)--establishment of a proton -motive force and the ATP formation * Transport across mitochondrial (inner) membrane: Active cotransport: H+ /Pyruvate (symport), ATP/ADP (antiport), Pi/H+ (symport) etc. Enzymatic shuttle-transports: glycerol phosphate shuttle, malate- aspartate shuttle, fatty acyl-carnitine transport *Other activities relaying on energized membrane: Pull calcium into Mit, Importing of specifically-targeted polypeptides to the Mit matrix from the cytosol
The Mit genetic information system Mit contain their own genetic system, which is separate and distinct from the nuclear genome of the cell and has descended from the genome of the original endosymbiotic bacteria that evolved into eukaryotic organelles, mitochondria Mit plays a essential role in cell apoptosis or antiapoptosis in response to exogenic or intrinsic apoptotic stimuli, Mit release Cytochrome c, AIF etc. or recruit cytosolic Bax to trigger the activation of apoptotic executors, and alter the energy/Redox metabolism in early phase of apoptosis. The activation of Bcl2-family protects the cell from apoptosis Mit is the main source and scavenger of oxygen free radicals. The Mit is not only the cells powerhouse, it is also its arsena The mitochondrion is important participant not only in eukaryotic cell life but also in active cell death
*The Mit genetic information system Mit contain their own genetic system, which is separate and distinct from the nuclear genome of the cell and has descended from the genome of the original endosymbiotic bacteria that evolved into eukaryotic organelles, mitochondria. * Mit. plays a essential role in cell apoptosis or antiapoptosis , in response to exogenic or intrinsic apoptotic stimuli, Mit release Cytochrome c , AIF etc. or recruit cytosolic Bax to trigger the activation of apoptotic executors, and alter the energy /Redox metabolism in early phase of apoptosis. The activation of Bcl2-family protects the cell from apoptosis. * Mit is the main source and scavenger of oxygen free radicals. The Mit is not only the cell’s powerhouse, it is also its arsenal. The mitochondrion is important participant not only in eukaryotic cell life but also in active cell death