胞科学 ell Science 蔡国平
细胞科学 Cell Science （13） 蔡国平
8 13 Cell signaling: communication between cells and their environment I Cell communication and what is cell signaling 2. Some of the basic characteristics of cell signaling systems 3. Main classes of cell-surface receptor proteins for secreted signaling molecules 4. G-protein-coupled cell-surface receptor-mediated cell signaling system 5. Receptor tyrosine kinases(RTKS): The receptors for most grow yth factors 6. Signaling that originate from cell-surface contact 7. Convergence, divergence and crosstalk among different signaling pathways and target-cell adaptation to a signaling ligand
§13. Cell signaling: communication between cells and their environment 1 Cell communication and what is cell signaling 2. Some of the basic characteristics of cell signaling systems 3. Main classes of cell-surface receptor proteins for secreted signaling molecules 4. G-protein-coupled cell-surface receptor-mediated cell signaling system 5. Receptor tyrosine kinases(RTKs): The receptors for most growth factors 6. Signaling that originate from cell-surface contact 7 . Convergence, divergence and crosstalk among different signaling pathways and target-cell adaptation to a signaling ligand
13. Cell signaling: communication between cells and their environment 13. 1 Cell communication and what is cell signaling For multi-cellular organisms, in addition to the transporting and exchange of material between cells, it is also essential for cell survival and their activities that cells communicate with their neighbors, monitor the conditions in their environment, and respond appropriately to a host of different types of stimuli that impinge on their surface Cells carry out these interactions by the mechanism known as cell signaling, in which information is relayed across the plasma membrane to the cell interior and often to the cell nucleus and these cell communication or signaling depend heavily on extracellular signal molecules or signals ( special domains or motifs )existing in extra-cellular macromolecules
13. Cell signaling: communication between cells and their environment 13.1 Cell communication and what is cell signaling For multi-cellular organisms, in addition to the transporting and exchange of material between cells, it is also essential for cell survival and their activities that cells communicate with their neighbors, monitor the conditions in their environment, and respond appropriately to a host of different types of stimuli that impinge on their surface. Cells carry out these interactions by the mechanism known as cell signaling, in which information is relayed across the plasma membrane to the cell interior and often to the cell nucleus and these cell communication or signaling depend heavily on extracellular signal molecules or signals (special domains or motifs ) existing in extra-cellular macromolecules
Actually, Cell communi- cation between single cell organisms also occurs by similar but much more simple mechanism,for example. yeast cells to be matting secrete some signal (A) molecules. which are as chemotactic factors to attract each other and mat (B)
Actually, Cell communication between single cell organisms also occurs by similar but much more simple mechanism , for example, yeast cells to be matting secrete some signal molecules, which are as chemotactic factors to attract each other and mat
Site of ● Extracellular ligand cell-cell ontact Activation of enzyme activity Change in cytoskeletal organizatie skeleton Change in ion erme Activation of DNA synthe Activation of RNA synthe Extracellular matrix Figure 15. 1 An overview of some of the ways that intracellu- loreinnale mav he initiated and the types of responses that can