Carcinogens and Tobacco-Induced cancers Cancer Likely Carcinogen Type Involvement PAH, NNK(major) 1, 3-butadiene, isoprene, ethylene oxide, ethyl carbamate, ald hydes, benzene, metals Larynx PAH Nasal NNK, NNN, other N-nitrosamines aldehydes Oral cavity PAH, NNK, NNN Esophagus NNN, other N-nitrosamines Lⅳer NNK, other N-nitrosamines, furan Pancreas NNK NNAL Bladder 4-Aminobiphenyl, other aromatic m Leukemia Benzene Holland-Frei cancer Medicine. 2010
Carcinogens and Tobacco-Induced Cancers Holland-Frei Cancer Medicine, 2010
Cumulative risk of lung cancer mortality among men in the UK who smoke Continued 15 smoking 10 Stopped age 50 St age Nevel smoked 55 65 AGE Vineis p et al. Jnci 2004
Cumulative risk of lung cancer mortality among men in the UK who smoke Vineis P, et al, JNCI 2004
Tobacco use and lung cancer mortality, United states, 1900-1999 100 4000 Per captia cigarette 3500 苞2500 Male lung cancer 2000 29号2538 Female lung cancer death rates 1905191019151920192519801935194019451950195519601965197019751980198519901995199 Holland-Frei cancer Medicine. 2010
Holland-Frei Cancer Medicine, 2010 Tobacco use and lung cancer mortality, United States, 1900-1999
Aflatoxins: HCC incidence in Qidong from 1972-2001 and primary prevention Qidong Jiangsu province Shanghal 0⑩6000 Poo dod 19701975198019851990199520002005 Kensler TW, et al, Nature Rev cancer, 2010
Aflatoxins: HCC incidence in Qidong from 1972–2001 and primary prevention Kensler TW, et al, Nature Rev Cancer, 2010
Other chemical carcinogens Aromatic Amines rehn, 1895, dye industry workers, bladder cancer nAT2 gene, rapid or slow metabolic phenotypes Benzene Petroleum products, rubber industry . Nonlymphocytic leukemia, lymphoma
Aromatic Amines •Rehn, 1895, dye industry workers, bladder cancer •NAT2 gene, rapid or slow metabolic phenotypes Benzene •Petroleum products, rubber industry •Nonlymphocytic leukemia, lymphoma Other chemical carcinogens