History of Identification of Human Carcinogens ramazzini 1700 nuns breast cancer pott 1775 chimney sweeps scrotal cancer . Rehn 1895 dye industry workers bladder cancer Unna 1894 sunlight exposure skin cancer .Yamagiwa 1915 animal model skin tumors
History of Identification of Human Carcinogens •Ramazzini 1700 nuns breast cancer •Pott 1775 chimney sweeps scrotal cancer •Rehn 1895 dye industry workers bladder cancer •Unna 1894 sunlight exposure skin cancer •Yamagiwa 1915 animal model skin tumors
History of Identification of Human carcinogens .The carcinogenic effects were first described in humans .In the 20th century experimental animals has preceded evidence from epidemiologic or case studies in humans The majority of human cancers probably result from the interaction of carcinogen along with intrinsic factors
•The carcinogenic effects were first described in humans. •In the 20th century, experimental animals has preceded evidence from epidemiologic or case studies in humans. •The majority of human cancers probably result from the interaction of carcinogen along with intrinsic factors. History of Identification of Human Carcinogens
The opinion that environmental agents are the principal causes of human cancers Although the overall incidence of all cancers is reasonably constant among countries, incidences of specific cancer types can vary up to several hundred fold. There are large differences in tumor incidence within populations of a single country Migrant populations assume the cancer incidence of their new environment within one to two generations Cancer rates within a population can change rapidly
•Although the overall incidence of all cancers is reasonably constant among countries, incidences of specific cancer types can vary up to several hundred fold. •There are large differences in tumor incidence within populations of a single country. •Migrant populations assume the cancer incidence of their new environment within one to two generations. •Cancer rates within a population can change rapidly. The opinion that environmental agents are the principal causes of human cancers
Polycyclic Aromatic Hydrocarbons(PAH) .Pott, 1775, chim ney sweeps, scrotal cancer . Carcinogens in soot and coal tar were PAhs ° Benzopyrene occupation smoking diet and air cutaneous occupational exposure skin cancer .Inhalation exposure: lung, bladder, pancreas and upper Gl
•Pott, 1775, chimney sweeps, scrotal cancer •Carcinogens in soot and coal tar were PAHs •Benzopyrene •Occupation, smoking, diet, and air •Cutaneous occupational exposure: skin cancer •Inhalation exposure: lung, bladder, pancreas and upper GI Polycyclic Aromatic Hydrocarbons (PAH)
Tobacco Smoke Carcinogens Recognized by the International Agency for Research on Cancer Chemical Class No. of Carcinogens Representative Carcinogens Polycyclic aromatic hydrocarbons Benzo[a]pyrene(BaP) (PAH)and their heterocyclic analogs Dibenz a, h]anthracene N-Nitrosamines 8 4-MethyInitrosamino)-1-(3-pyridyl)-1- utanone(NNK N-Nitrosonornicotine(NNN) Aromatic amines 12 4-Aminobiphenyl 2-Naphthy lal Aldehydes 2 Formaldehyde Acetaldehyd Phenols Catechol Caffeic acid Volatile hydrocarbons 3 Benzene 1.3-Butadiene isoprene Other organics Ethylene oxide Acrylonitrile Inorganic compounds Cadmium Polonium-210 Holland-Frei cancer Medicine. 2010
Tobacco Smoke Carcinogens Recognized by the International Agency for Research on Cancer Holland-Frei Cancer Medicine, 2010