IRONMETABOLISMIron stores and utilizingliver食物铁血红素铁spleenBoneHb合成SImarrow肌红蛋白合含铁酶(fig2)HEMATOLOGY/ONCOLOGY,CHILDREN SHOSPITAL
IRON METABOLISM • Iron stores and utilizing HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L ( f i g2) 食物铁 血红素铁 S I live r s p le e n B o n e m a rro w H b合成 肌红蛋白 含铁酶
老IRONMETABOLISMReguirementandexcretiondemandexcretion1mg/d1mg/dadults4mo-3yrlmg//kg(15ug/kg/d)2mg/kgprematureHEMATOLOGY/ONCOLOGY,CHILDREN'S HOSPITAL
IRON METABOLISM • R e q u i r e m e n t and excretion excretion 1mg/d (15 ug/kg/d) adults 4mo-3yr prem ature d e m a nd 1mg/d 1m g//kg 2mg/kg HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L
IRONMETABOLISMSummaryand key points-Ironcompartmentorfunction·Hb.Stores (SF-hemosiderin):Myloglobin:Enzyme.Serum iron-Iron sources-Ironabsorption andtransportation·SF/SI/TIBC-Irondailyrequirementand excretionHEMATOLOGY/ONCOLOGY,CHILDREN SHOSPITAL
IRON METABOLISM • Summary and key points –Iron compartment or function • H b • Stores (SF - hemosiderin) • Myloglobin • E n z y me • Serum iron –Iron sources –Iron absorption and transportation • S F /SI /TIBC –Iron daily requirement and excretion HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L
ETIOLOGY＆PATHOGENES·ETIOLOGYbor iron storesPoor dietary intake ofiron*OverdevelopChronic bleeding- Absorption problemsHEMATOLOGY/ONCOLOGY,CHILDREN SHOSPITAL
E T I O L O G Y & P A T H O G E N E S I S • ETIOLOGY –Poor iron stores –Poor dietary intake of iron* –Overdevelop –Chronic bleeding –Absorption problems HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L