一、抗菌药物的体内过程 1.吸收吸收过程药时曲线AUC生物利用度 2.分布表观分布容积分布特性(骨、前列腺、脑脊液、胎儿) 3.消除血浆半衰期(t12)肝、肾消除胆汁 二、药动学(PK)-药效学结合模型(PD)

概述 一、定义 二、意义 在药理学研究中的作用血药浓度时间曲线对临床用药具指导意义

一、化学药,生物药:(资料27) 1类,全新:单次(3个剂量),多次,口服者加食物影响,CT曲线药代特征药代参数组织分布蛋白结合,消除特征(尿,粪胆),结构转化药酶影响 2类,新途:第20条说明速缓控释者做单次多次 4类,改根:单次为主 5类,改型:同2类新途

一、药代动力学研究中的生物样品分析 二、临床前药代动力学研究 三、人体生物利用度和生物等效性 四、常用动力学软件介绍

一、什么是临床药动学? 二、临床药动学有哪些研究内容? 三、临床药动学研究与药物临床应用有何关系? 四、新药临床药动学研究有哪些基本要求? 五、新药临床药动学研究记录与保存文件有哪些要求?

Introduction Growth and growth disorders Adrenal disorders and sexual development abnormalities Thyroid disorders Disorders of calcium and phosphorus metabolism Diabetes mellitus and hypoglycemia Other disorders: obesity, autoimune

Introduction GHD is a disorder involves the pituitary gland Pituitary gland does not produce enough GH Growth velocity is slower than normal GHD can occur at any age

Introduction Growth and growth disorders Adrenal disorders and sexual development abnormalities Thvroid disorders Disorders of calcium and phosphorus metabolism Diabetes mellitus and hypoglycemia Other disorders: obesity, autoimune endocrinopathies, tumor, inborn metabolic

Introduction GHD is a disorder involves the pituitary gland Pituitary gland does not produce enough gh Growth velocity is slower than normal GHD can occur at any age

One pairofchromosome 21 was seen in peripheral lymphocytes of normal person 15