B. Conjunctiva synthesis in vivo (regeneration) 1. Structure and function of conjunctiva. 2. Clinical effects of conjunctival scarring. 3. Anatomically well-defined defect. 4. Synthesis of conjunctival stroma, followed by re-epithelialization
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Methodology of Organ Synthesis A Skin B Conjunctiva C. Peripheral nerves D. simplest synthetic pathways
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TISSUES COMPRISING JOINTS Permanent Regeneration Prosthesis Scaffold Bone
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ELEMENTS FOR TISSUE REGENERATIONENGINEERING CELLS Autologous, Adult (pulp and bone marrow stromal stem cell)
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TISSUES COMPRISING JOINTS Permanent Regeneration Prosthesis Scaffold
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Outline 1. Irreversible injury 2. Regenerative and nonregenerative tissues 3. Antagonistic relation between contraction and regeneration 4. Present theory: Selective inhibition of contraction necessary but not sufficient for regeneration 5. Mechanism
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JOINT REPLACEMENT PROSTHESES Fit -Anatomy Function -Kinematics; Range of Motion Fixation Bone cement, bone interdigitation with an irregular surface, bone ingrowth into a porous coating Tribology
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BIOMATERIALS-TISSUE INTERACTIONS BIOMATERIAL TISSUE Strength ize scale IOnm 100nm lum 10 um 100 um Imm Modulus of Elasticity Fracture mechanics
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B. Cell-Matrix Interactions A. How cells pull onto and deform the matrix to which they attach themselves. B. Cell-matrix interactions control the spontaneous closure of wounds in organs. C. What happens when regeneration is induced?
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C. Cell-Matrix Interactions A. How cells pull onto and deform the matrix to which they attach themselves. B. Cell-matrix interactions control the spontaneous closure of wounds in organs. C. What happens when regeneration is induced?
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