随着硏究者可用的序列与结枃信息的爆炸式增长,生物信息学领域,或更精确地说是计算生 物学领域,在基础生物医疗问题的研究中起着越来越大的作用。计算生物学家面临的挑战, 尤其是由人类基因组计划以及其它测序工作生成的大量数据带来的挑战,将对发现基因和设 计分子模型、定点突变,以及其它有可能发现基因与蛋白质的结构与功能的未知关系的实验 有所帮助

目录 译者序 编者序 1.因特网与生物学家 1.1因特网基础 1.2与因特网连接 1.3电子邮件 1.4文件传输协议 1. 5 GOPHER

ART TK used to unravel involve of the immune mental conditions. Ho of unknown add ambiguity to the in of lymphocytes quently repea Addition of Expression Profile of Diffuse Large B-cell Lymphoma. plified to the extent that

has declined become the se led only by heart di person in three in the that one in five will die spective, cancer cells ca ch ing particular a Cancerous melanoma cells. nized by the ir d cers Cancer: Origin and Terminology The final section des

immunology, refers to the act of transferring cells, tissues, or organs from one site to another. The desire to accomplish transplants stems from the realization that many diseases can be cured by implantation of a healthy organ, tissue, or cells(a graft)from one individual (the donor)to another in need of the transplant(the recipient or

realized that the immune system could go awry and, instead of reacting against foreign antigens, could focus its attack on self-antigens. He termed this con- dition\horror autotoxicus \We now understand that while mechanisms of self-tolerance normally protect an individual from potentially self-reactive lymphocytes, there are failures They result in an inappropriate response of the immune system against self-components termed autoimmunity In the 1960s, it was believed that all self-reactive lymphocytes

lure can have dire consequences. Nude Mouse (nu/nu) elf and begins to attack hich is Primary Immunodeficiencies AIDS and Other Acquired or Secondary Immunodeficiencies at birth differentiated from immunodeficiencies in which the non- specific mediators of innate immunity, such as phagocytes or ed. Immunodeficiencies are conve- by the type or the developmental stage of overall cellular de g the locations of prevennon stra

the early vaccination trials of Edward Jenner and oneering efforts, vac nce of diseases such ng cougl Vaccination with DN A Active and Passive Immunization Designing Vaccines for Active Immunization mWhole-Organism Vaccines Purified Macromolecules as Vaccines Recombinant-Vector Vaccines DNA Vaccines Multivalent Subunit Vaccines mmon usage. Experience has shown that not every vaccine

susceptible host, a series of coordinated events must rcumvent both innate and adaptive immunity. One of the first and most important features of host innate immunity is the barrier provided by the epithelial surfaces of the skin and the lining of the gut. The difficulty of penetrat- ing these epithelial barriers ensures that most pathogens never gain productive entry into the host. In addition to pro viding a physical barrier to infection, the epithelia also pro duce chemicals that are useful in

effector molecules that act to remove antigen b ren various mechanisms described in previous chap es antigen without A Second Exposure to Poison Oak May Result in Delayed-Type Hypersensitivity Gell and Coombs Classification IgE-Mediated (Type I) Hypersensitivity Antibody-Mediated Cytotoxic(Type) Hypersensitivity aImmune Complex-Mediated (Type Ill) Hypersensitivity