Different changes of DNA behavior re- address〔行为矫正) (death and unhealthy), Wnlchad Chapter8: Mutation(突变)isba needs to be repaired Chapter9: Recombination(重组) is good (diversity in a species beautiful),which is promoted Chapter10: Transposition(转座) is not bad because it is not repaired(benefit?)
Different changes of DNA -behavior re-address (行为矫正） ◼ Chapter 8: Mutation (突变) is bad (death and unhealthy), which needs to be repaired ◼ Chapter 9: Recombination (重组) is good (diversity in a speciesbeautiful), which is promoted ◼ Chapter 10: Transposition (转座) is not bad, because it is not repaired. (benefit?)
The consequence of high rates of mutation ■ Mutation in germ line(生殖细胞) would destroy the species ■ Mutation in soma(体细胞) would destroy the individual Maintenance of the correctness of the DNA sequence is definitely crucial for living organisms. Keeping the error rate as low as 10-10 is so expensive
The consequence of high rates of mutation ◼ Mutation in germ line (生殖细胞) would destroy the species ◼ Mutation in soma (体细胞) would destroy the individual. Maintenance of the correctness of the DNA sequence is definitely crucial for living organisms. Keeping the error rate as low as 10-10 is so expensive
Be fair(公正) and serious (严肃) to science The points that i absolutely do not agree with Waston et al. 1. Mutation is not good, it could not be responsible for biodiversity. 2. Transposition is different from mutation because(1) producing mechanism is different;(2)no mechanism to correct it;(2) existing in nature in a well controlled manner(10-5)。(物种起源)
Be fair (公正) and serious (严肃) to science The points that I absolutely do not agree with Waston et al. 1. Mutation is not good, it could not be responsible for biodiversity. 2. Transposition is different from mutation because (1) producing mechanism is different; (2) no mechanism to correct it; (2) existing in nature in a wellcontrolled manner (10-5). (物种起源)
Two important sources for mutation (unavoidable) a Inaccuracy in DNA replication (10-7 is not accurate enough) Errors(错误) a Chemical damage to the genetic material (environment) Lesions(损害伤害 arose from spontaneous damage) Damage(损害伤害 caused by chemica agents and radiation
Two important sources for mutation (unavoidable) ◼ Inaccuracy in DNA replication (10-7 is not accurate enough) Errors (错误) ◼ Chemical damage to the genetic material (environment) Lesions (损害,伤害arose from spontaneous damage) Damage (损害,伤害 caused by chemical agents and radiation
To repair an error or damage First, detect the errors Second, mend/repair the errors or lesions in a way to restore the original dNa sequence
To repair an error or damage First, Detect the errors Second, Mend/repair the errors or lesions in a way to restore the original DNA sequence