C. Non -immune mechanisms glomerular hypertension hyperlipidemia ( LDl- cho) advanced glycosylation end products (protein) glomerulosclerosis
C. Non –immune mechanisms • glomerular hypertension • hyperlipidemia (LDL- Cho) • advanced glycosylation end products (protein) glomerulosclerosis
Inflammation Mediators of inflammation A group of molecules which act as mediators of inflammation and complicated biological function Origin of inflammation mediators in kidney Extrinsic Cells in kidney infiltrative neutrophil, lymphocyte, mononuclear macrophage, platelet Intrinsic cells in kidney Mesangial cells, tubular cells, endothelial cells
Inflammation • Mediators of inflammation – A group of molecules which act as mediators of inflammation and complicated biological function • Origin of inflammation mediators in kidney – Extrinsic Cells in kidney • infiltrative neutrophil, lymphocyte, mononuclear macrophage , platelet – Intrinsic cells in kidney • Mesangial cells, tubular cells, endothelial cells
Mediators of inflammation active oxygen and active nitrogen lipids complements cytokines chemotatic factors adhesion molecules growth factors vasoactive substances
Mediators of inflammation - active oxygen and active nitrogen - lipids - complements - cytokines - chemotatic factors - adhesion molecules - growth factors - vasoactive substances
Effects of the inflammation mediators To arouse or promote proliferation of cells accumulation of extracellular matrix changes of histological structure expression of immunomodulating molecules and adhension molecules
To arouse or promote - proliferation of cells - accumulation of extracellular matrix - changes of histological structure - expression of immunomodulating molecules and adhension molecules Effects of the inflammation mediators
Mechan i sms of Pr imary GN Immune non-Immune Essent ial in Essential in the the initiation progress ive per iod infl ammat ion I nf l ammatory cells Extrinsic cells Intrinsic cells neutrophil, lymphcyte mesangial cells mononuclear macrophage epithellal cells platelet, tubular cells endothelial cells Inf l ammat ion mediators cyto ines TNFx,L-1β growth factors TGFβ.,PDGF chemotatic factors MCP-1IL-8 comp l ements, vasoactive substances active oxygen and active nitrogen Coagu lat ion and fibrolysis system, enzyme Glomerular injuries
Mechanisms of Primary GN immune non-immune inflammation Inflammatory cells Extrinsic cells Intrinsic cells neutrophil, lymphcyte mesangial cells mononuclear macrophage epithelial cells platelet, tubular cells endothelial cells Inflammation mediators cytokines TNF,IL-1 growth factors TGF,PDGF chemotatic factors MCP-1,IL-8 complements, vasoactive substances active oxygen and active nitrogen Coagulation and fibrolysis system, enzyme Glomerular injuries Essential in the initiation Essential in the progressive period