Caspase substrates lCAD:DNA降解 PARP:破坏DNA修复 破坏细胞骨架: gelsolin, laminA 灭活凋亡抑制蛋白:Bc-2 FasL Fas etc Procaspase-8 C-FLIP DNA损伤 Bid Bcl-x C t Bid cytochrome c AIR Caspase-3 调亡复合体 Smac/DIABLO Apaf-1 a procaspase HtrA2 de ath substrates ICAD IAPs ICAD CAD CAD 000000
Caspase substrates: •ICAD：DNA降解 •PARP：破坏DNA修复 •破坏细胞骨架：gelsolin, laminA •灭活凋亡抑制蛋白：Bcl-2 • etc Cleavage of death substrates
Role of endonuclease Signaling degrade DNA activation Endonuclease Ca2+Mo Zn M12 180-200bp 1.000 60
Role of Endonuclease: degrade DNA 180-200 bp H1 Zn2+ Ca2+ Mg2+ Endonuclease Signaling activation