Immediate and Late-PhaseReactionsWJHWheal-and-flare reactionLate-phase reaction(lastsupto30minpost(developsapproximatelyinjection)eight hours later andpersists several hours)
IgEresponseisalocaleventsiteof allergenentrylocal synthesis results in sensitization oflocal mastcellsspillover of IgE enters circulation andsensitizes mast cells and basophilssystemically