AdrenoceptorantagonistdrugsAdrenoceptorantagonistdrugs(AdrenoceptorblockingdrugsA kind of drugsthat can combinetohavelittleandadrenoreceptorornomimictheaction of NA, butpreventbyactivationadrenergicreceptortransmitter and related agonist.According to receptor selectivity, it can beclassified to three groups
Adrenoceptor antagonist drugs Adrenoceptor antagonist drugs （Adrenoceptor blocking drugs） A kind of drugs that can combine to adrenoreceptor and have little or no mimic action of NA，but prevent the receptor activation by adrenergic transmitter and related agonist. According to receptor selectivity, it can be classified to three groups
Adrenoceptorantagonistdrugsdrugsgroupsareceptor antagonistphentolaminephenoxybenzamineαi α2 R antagonistPrazosin, terazosinα R antagonistyohimbineα2 R antagonistβ receptor antagonistPropranolol, timolol, pindololβ β2 R antagonistAtenolol, metoprololβ, R antagonistbutoxamineβ2 R antagonistlabetalolαβ receptor antagonist
Adrenoceptor antagonist drugs groups drugs αreceptor antagonist α1 α2 R antagonist phentolamine phenoxybenzamine α1 R antagonist Prazosin, terazosin α2 R antagonist yohimbine β receptor antagonist β1 β2 R antagonist Propranolol, timolol, pindolol β1 R antagonist Atenolol, metoprolol β2 R antagonist butoxamine αβ receptor antagonist labetalol
areceptorantagonistareceptor antagonist may be reversible or irreversiblein their inter action with these receptor.classification:phentolamine酚妥拉明short-duration grouptolazoline妥拉唑啉Prazosin andanalogsreversibleantagonistsphenoxybenzamine酚芒明long-duration groupirreversible antagonist
αreceptor antagonist ⚫ αreceptor antagonist may be reversible or irreversible in their inter action with these receptor. ⚫ classification： short-duration group phentolamine 酚妥拉明 tolazoline 妥拉唑啉 Prazosin and analogs reversible antagonists long-duration group phenoxybenzamine酚苄明 irreversible antagonist
100100osnControlControl505010μmol/L0.4μmol/L0.8 μmol/L20 μmol/L/-2.4201601.2 1080Norepinephrine (umol/L)Noroninanhrine/mmol/l
areceptorantagonisteffect1 blood vessels and blood pressureblock a receptordirect relaxes blood vessels musclevasodilationblood pressurelepinephrinereversalheartreflex cardiac stimulationpresynapsea, R blocking , negativefeedback
αreceptor antagonist effect 1 blood vessels and blood pressure block α receptor direct relaxes blood vessels muscle vasodilation blood pressure epinephrine reversal 2 heart reflex cardiac stimulation presynapseα2 R blocking ，negative feedback