Scientific knowledge Base Pain Mechanism of Pain Two main mechanism of pain: neuroregulation gate-control theory. WWW.IVSKY.COM
Mechanism of Pain Two main mechanism of pain: neuroregulation gate-control theory. 1
Scientific knowledge Base Pain Neuroregulation Neuroregulators Neurotransmitters convey electrical impulses through the synaptic cleft between two nerve fibers,which include substance P,serotonin and prostaglandins. Neuromodulators are believed to act indirectly by increasing or decreasing the effects of particular neurotransmitters
Neuroregulation Neuroregulators : • Neurotransmitters convey electrical impulses through the synaptic cleft between two nerve fibers, which include substance P, serotonin and prostaglandins. • Neuromodulators are believed to act indirectly by increasing or decreasing the effects of particular neurotransmitters. 1
伤害性刺激 神经调节 受损部位释放致痛物质 疼痛感受器 脊髓 丘脑 大脑皮层 产生痛感
Scientific knowledge Base Pain Gate-Control Theory of Pain Melzack and Wall's gate-control theory(1965):Pain impulses can be regulated or even blocked by gating mechanisms in the central nervous system. Pain impulses can pass through when a gate is open and may be blocked when a gate is closed
Gate-Control Theory of Pain • Melzack and Wall’s gate-control theory(1965) : Pain impulses can be regulated or even blocked by gating mechanisms in the central nervous system. • Pain impulses can pass through when a gate is open and may be blocked when a gate is closed. 1
Scientific knowledge Base Pain When A-delta and C neurons work dominantly,they release substance P to help impulses transmitted through the gating mechanisms.And the patient feels pain.On the contrary. when mechanoreceptor,thicker,faster A- beta neurons work mainly,they release inhibiting neurotransmitters to close gating mechanisms
When A-delta and C neurons work dominantly, they release substance P to help impulses transmitted through the gating mechanisms. And the patient feels pain. On the contrary . when mechanoreceptor, thicker, faster A- beta neurons work mainly, they release inhibiting neurotransmitters to close gating mechanisms. 1