Table 1.1. Features of different conformations of the dna double helix B-DNA Conformation a ZDNA Feature DNA Right-handed Left-handed Helical diameter (nm 2.37 2.55 184 Rise per base pair 034 0.29 0.37 (nm) Distance per 3.4 3.2 4.5 complete turn(pitch) (nm) Number of base pairs 12 per complete turn Topology of major wide, deep Narrow, deep Flat groove Topology of minor Narrow shallow Broad, shallow Narrow, deep groove Other variations include B-C-C, C-D-,E-and T-DNAs
Table 1.1. Features of different conformations of the DNA double helix Feature B-DNA Conformation ADNA Z-DNA Type of helix Right-handed Right-handed Left-handed Helical diameter (nm) 2.37 2.55 1.84 Rise per base pair (nm) 0.34 0.29 0.37 Distance per complete turn (pitch) (nm) 3.4 3.2 4.5 Number of base pairs per complete turn 10 11 12 Topology of major groove Wide, deep Narrow, deep Flat Topology of minor groove Narrow, shallow Broad, shallow Narrow, deep Other variations include B-, C-, C-, C-, D-, E- and T-DNAs
G4 DNA G-quadruplexes, g-tetraplexes a b NN、N H "NN H N-H TYO-H-N R NN
G4 DNA • G-quadruplexes, g-tetraplexes
G4 DNA Intermolecular G4 DNA Intramolecular G4 DNA G4 DNA at t-loop (ciliate telomeres at telomere end
G4 DNA
G4 DNA Besnard e, et al. 2012. Unraveling cell type-specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs. Nat Struct mol bio 19: 837-844 Gilbert DM. 2012. Replication origins run ltra)deep. Nat Struct Mol Biol 19: 740 742
• Besnard E, et al. 2012. Unraveling cell type–specific and reprogrammable human replication origin signatures associated with G-quadruplex consensus motifs. Nat Struct Mol Biol 19:837-844. • Gilbert DM. 2012. Replication origins run (ultra) deep. Nat Struct Mol Biol 19:740- 742. G4 DNA
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1.2 RNA and the transcriptome