Part 1 Studying Genome 1. Genomes, Transcriptomes and proteomes 2. Studying DNA 3. Mapping Genomes 4. Sequencing Genomes 5. Understanding a Genome Sequence 6. Understanding how a genome Functions
Part 1 Studying Genome 1. Genomes, Transcriptomes and Proteomes 2. Studying DNA 3. Mapping Genomes 4. Sequencing Genomes 5. Understanding a Genome Sequence 6. Understanding How a Genome Functions
Chapter 1 Genomes, Transcriptomes and Proteomes DNA: gene and the genome RNA and the transcriptome Protein and the proteomes
Chapter 1 Genomes, Transcriptomes and Proteomes • DNA: gene and the genome • RNA and the transcriptome • Protein and the Proteomes
1.1 DNA Human cell ③ Human family Nuclear genome Mitochondrial genome 才
1.1 DNA
GENOME Transcription TRANSCRIPTOME RNA copies of the active protein-coding genes Translation PROTEOME The cells repertoire of proteins Figure 1.2 Genomes 3( Garland Science 2007)
Figure 1.2 Genomes 3 (© Garland Science 2007)
1.1.1 Genes are made of dna 1903. WS Sutton had realized that the inheritance patterns of genes paralleled the behavior of chromosomes during cell division Protein vs dna The most conclusive way to identify the chemical composition of genes would be to purify some and subject them to chemical analysis. But nothing like this had ever been attempted and it was not clear how it could be done. Ironically, the experiment was performed almost unwittingly by a group of scientists who did not look upon themselves as molecular biologists and who were not motivated by a curiosity to know what genes are made of
1.1.1. Genes are made of DNA • 1903, WS Sutton had realized that the inheritance patterns of genes paralleled the behavior of chromosomes during cell division. • Protein vs DNA • The most conclusive way to identify the chemical composition of genes would be to purify some and subject them to chemical analysis. But nothing like this had ever been attempted and it was not clear how it could be done. Ironically, the experiment was performed almost unwittingly by a group of scientists who did not look upon themselves as molecular biologists and who were not motivated by a curiosity to know what genes are made of