:△( Deration& actuation ol nsmemarane receptor 来 A t Potel Tanslation Nues mRNA export J5 mRNA packaging trarscnoto anc mRNA processing 了 pdlyadarmytton 上罐 Comate Codad italian Chromatin Figure 2. A Contem porary View of Gene Expression Recent findings suggest that each step regulating gene expression (from transcripton to translaton) is a subdivision of a continuous process. In this contemporary view of gene expression, each stage is physically and functionally connected to the next, ensuring that there is efficient transfer between manipulations and that no individual step is omitted (see text for details)
Something new 290% of endogenous yeast splicing is posttranscriptional Tardiff DF, Lacadie SA, Rosbash M: A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional. Mol/ 2006, 24: 917-929 Alexander RD, Innocente SA, Barrass JD, Beggs JD: Splicing- dependent RNa polymerase pausing in yeast. Mol Cell 2010, 40:582-593 Tilgner H, Knowles DG, Johnson R, Davis CA, Chakraborty S, Djebali S, Curado J, Snyder M, Gingeras TR, Guigo R: Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for IncRNAs, Genome res 2012. 22: 1616-1625
Something new • ≥90% of endogenous yeast splicing is posttranscriptional. • Tardiff DF, Lacadie SA, Rosbash M: A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional. Mol Cell 2006, 24:917-929. • Alexander RD, Innocente SA, Barrass JD, Beggs JD: Splicingdependent RNA polymerase pausing in yeast. Mol Cell 2010, 40:582-593. • Tilgner H, Knowles DG, Johnson R, Davis CA, Chakrabortty S, Djebali S, Curado J, Snyder M, Gingeras TR, Guigó R: Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs. Genome Res 2012, 22:1616-1625