《生粉莪制药》 专题研 庄园 副研究员 国家免疫生物制品工程技术研究中心 暨全军免疫生物制品重点实验室
庄 园 副研究员 国家免疫生物制品工程技术研究中心 暨全军免疫生物制品重点实验室 专题研讨课 《生物技术制药》
一题 研讨主题 “胃漓兔蜜治疗的研究略” vAccine fluzone
微生物与生化药学教研室 研讨主题 “胃癌免疫治疗的研究策略
Introduction of concept Cancer Immunoediting”(难点) Immunotherapy in gastric cancer (重点) Immunity cancer-editing Clinic to basic(启示)
•Introduction of concept “Cancer Immunoediting” (难点) •Immunotherapy in gastric cancer (重点) • “Immunity cancer-editing” Clinic to basic (启示)
Introduction ● Immunity- nature??? o Recognization----self or nonself immunogenicity(免疫原性) o Balance immune tolerance immunoreactivity(免疫反应性)orRE5 Iune response Cancer Immunoediting???
Introduction • Immunity----nature ??? • Recognization----self or nonself • Balance------immune tolerance or immune response “Cancer Immunoediting???” immunogenicity (免疫原性) immunoreactivity (免疫反应性)
Three Ways for Self Antigens to Become Tumor Antigens MHC Peptides C molecules Mutant Normal protein Modified proteins Overexpressed protein rotein umor ce Tumor cell Tumor cell 质变 量变 伪装 Mutation Overexpression Post-Translational Modification 2 Self Nonself
Three Ways for Self Antigens to Become Tumor Antigens Self Nonself 质变 量变 伪装