immunodeficient mice免疫缺陷小鼠 Carcinogen 致癌剂 200 days 100 mice Immunocompetent Carcinogen E53E 40 致癌剂 200 days 820 160 Time after carcinogen treatment (days) mmunocompetent mice免疫正常小鼠 The immune status of mice is a critical determinant of their susceptibility to tumors induced by chemical carcinogen 免疫状态影响成瘤
The immune status of mice is a critical determinant of their susceptibility to tumors induced by chemical carcinogen 免疫状态影响成瘤 Immunodeficient mice 免疫缺陷小鼠 Immunocompetent mice 免疫正常小鼠 Carcinogen 致癌剂 200 days Carcinogen 致癌剂 200 days
Primary tumor Tumor Inject into Monitor Growth growing In cell line naive Wt tumor profile recipients growth Edited progressor Immunocompetent Day 30 Mouse免疫正常小鼠 Immunocompetent Mouse免疫正常小鼠 多 Unedited progressor 0 Day 30 Immunodeficient Unedited Mouse免疫缺陷小鼠 regressor 0 Day 3 Tumors in immunocompetent mice are qualitatively different from tumors in immunodeficient mice 不同免疫状态下所成的瘤性质有差异
Tumors in immunocompetent mice are qualitatively different from tumors in immunodeficient mice 不同免疫状态下所成的瘤性质有差异 Primary tumor growing in: Tumor cell line Inject into naive WT recipients Monitor tumor growth Growth profile Immunocompetent Mouse 免疫正常小鼠 Immunodeficient Mouse 免疫缺陷小鼠 Edited progressor Unedited progressor Unedited regressor Immunocompetent Mouse 免疫正常小鼠
Inn atdolpbimermibnunity Macrophage B cell Tcell 巨噬细胞 Dentritic cell /o Natural killer cell 树突状细胞包 自然杀代 Basophil Mast carbody 嗜碱性粒细胞 肥大痴 Eosinophil 嗜配胞 Neutrophil Cat中性細跑
Innate Immunity Basophil 嗜碱性粒细胞 Eosinophil 嗜酸性粒细胞 Neutrophil 中性粒细胞 Macrophage 巨噬细胞 Natural killer cell 自然杀伤细胞 Dentritic cell 树突状细胞 Mast cell 肥大细胞 B cell T cell CD4+ T cell CD8+ T cell Adoptive Immunity Antibody 抗体
Innate Immunity Dentritic cell 树突状细胞 Phagocytosis various stress-induced 吞噬作用 genes“应急反应基因” Tumor cell 肿瘤细胞 Natural killer cell 自然杀伤细胞 Tumor-cell peptides 肿瘤细胞相关多肽 Macrophage 巨噬细胞 Heat-shock proteins O热休克蛋白
Innate Immunity Natural killer cell 自然杀伤细胞 Dentritic cell 树突状细胞 Macrophage 巨噬细胞 Tumor cell 肿瘤细胞 Tumor-cell peptides 肿瘤细胞相关多肽 Heat-shock proteins 热休克蛋白 Phagocytosis various stress-induced 吞噬作用 genes “应急反应基因