Cell and tissue injuryReversibleinjury--fatty changeDefinition:The accumulationof fatinnon-fattyparenchymalcells.脂肪变：实质细胞内脂肪的异常蓄积Liver,heart,kidneysand otherorgansGross:enlarges,yellow,soft,andgreasyLM:Thefatty change appearsas clearvacuoleswithinparenchymalcells.肉眼：器官体积增大，淡黄色，边缘圆钝，切面呈油腻感光镜：细胞内出现边缘较整齐的大小不等的圆形空泡，苏丹Ⅲ皇桔红色，钱酸皇黑色
Logo Definition: The accumulation of fat in nonfatty parenchymal cells. 脂肪变: 实质细胞内脂肪的异常蓄积 Cell and tissue injury Reversible injury-fatty change Liver, heart, kidneys and other organs 肉眼: 器官体积增大，淡黄色，边缘圆钝，切面呈油腻感 光镜: 细胞内出现边缘较整齐的大小不等的圆形空泡， 苏丹Ⅲ呈桔红色，锇酸呈黑色 Gross: enlarges, yellow, soft, and greasy. LM: The fatty change appears as clear vacuoles within parenchymal cells
Cell and tissue injuryFatty change of liver游离脂肪酸alcoholabuse醋酸脂肪酸protein malnutrition一甘油磷脂氧化成为酮体及C02obesity磷脂V胆固醇酯hepatotoxin甘油三酯diabetes脂载蛋白脂蛋白肝脂肪变LUYU
Logo Fatty change of liver Cell and tissue injury ⚫ alcohol abuse ⚫ protein malnutrition ⚫ obesity ⚫ hepatotoxin ⚫ diabetes
Cell and tissueinjuryIntracellularaccumulations---fatty changeEnlarged,yellow,soft(section)greasy
Logo Intracellular accumulations -fatty change Cell and tissue injury
Cell and tissue injuryFattychangeof liverLM:SmallvacuolesaroundnucleusIcoalescelargevacuolesthatdisplacethenucleus to the periphery of the cell
Logo LM: Small vacuoles around nucleus ↓coalesce large vacuoles that displace the nucleus to the periphery of the cell. Fatty change of liver Cell and tissue injury
Cell and tissue injurySpecialstainingFatty change ofSudan IIl : orange redliverOsmicacid:black
Logo Special staining Sudan III : orange red Osmic acid: black Fatty change of liver Cell and tissue injury