Cell and tissue injuryMorphologic changes--Reversible injury各种细胞损伤的早期改变为ATP减少、细胞膜完整性缺失、蛋白合成下降、细胞骨架损伤和DNA损伤。在一定限度内损伤的改变为可逆的，传统形态学上称变性(Degeneration)When cellular injury is sublethal and sustained,cells and tissues tend to accumulate substancesin abnormal quantities. These materials may beendogenousorexogenous.变性指细胞或细胞间质受损伤后，由于代谢障碍，使细胞内或细胞间质内出现异常物质或正常物质异常蓄积的现象，通常伴有细胞功能低下。Logb
Logo Morphologic changes-Reversible injury 各种细胞损伤的早期改变为ATP减少、细胞膜完整性缺 失、蛋白合成下降、细胞骨架损伤和DNA损伤。在一 定限度内损伤的改变为可逆的，传统形态学上称变性 （Degeneration） 变性指细胞或细胞间质受损伤后，由于代谢障碍，使细胞内或细 胞间质内出现异常物质或正常物质异常蓄积的现象，通常伴有细 胞功能低下。 When cellular injury is sublethal and sustained, cells and tissues tend to accumulate substances in abnormal quantities. These materials may be endogenous or exogenous. Cell and tissue injury
Cell and tissue injury--Morphologicchanges细胞肿胀Cellularswellingreversiblecell injury脂肪变Fattychange脂质lipids蛋白质proteins淀粉样变AmyloidchangeIntra(extra)-cellularaccumulations糖原glycogen玻璃样变hyalinechange黏液样变mucoidchange病理性色素沉着Pigments病理性钙化Pathologiccalcification
Logo -Morphologic changes 脂质 lipids reversible cell injury 细胞肿胀 Cellular swelling 脂肪变 Fatty change Intra (extra)-cellular accumulations 蛋白质 proteins 淀粉样变 Amyloid change 玻璃样变 hyaline change 黏液样变 mucoid change 病理性色素沉着 Pigments 糖原 glycogen 病理性钙化Pathologic calcification Cell and tissue injury
Cell and tissue injuryReversible injury--cellular swellingThecommonestand earliestform ofcellinjuryfromalmostallcauses.Hypoxia infection intoxicationmitochondriainjuryATPINa+-K+pumpdysfunctionIntracellularaccumulationofNa+andH2oThe common site---liver, kidney , heart
Logo The common site- liver, kidney , heart Reversible injury-cellular swelling Cell and tissue injury The commonest and earliest form of cell injury from almost all causes. Hypoxia infection intoxication mitochondria injury ATP↓ Na+-K+ pump dysfunction Intracellular accumulation of Na+ and H2O
CellandtissueinjuryReversibleinjury--cellularswellingGrossly:Theaffectedorganisenlarged due toswelling.The cut surface bulges outwards andisslightlyopaque肿大，包膜紧张，切面隆起，边缘外翻，混浊无光，如沸水烫过CellularswellingofliverLogo
Logo Reversible injury-cellular swelling Grossly: The affected organ is enlarged due to swelling. The cut surface bulges outwards and is slightly opaque. 肿大，包膜紧张，切面隆起，边缘外翻，混浊无光，如沸水烫过 Cell and tissue injury Cellular swelling of liver
Cell and tissue injuryReversibleinjury--cellularswellingLM: The cells are swollenSmallclearvacuolesareseeninthe cells病变初期，细胞质内出现的红染细颗粒状物。若水钠进一步积聚，细胞基质高度疏松呈空泡状，其极期称为气球样变NormalcellGranularitychangeHydropicchangeViralhepatitis
Logo Reversible injury-cellular swelling Normal cell Granularity change Hydropic change Viral hepatitis LM: The cells are swollen. Small clear vacuoles are seen in the cells. 病变初期，细胞质内出现的红染细颗粒状物。若水钠进一步 积聚，细胞基质高度疏松呈空泡状，其极期称为气球样变 Cell and tissue injury