6. Three possible reading frames 5 AUGAAAG C AAUUUUCGUA A AAG GG GUG GC G CAC UU C CUG A K F G)( W (S 5 AUGAAAGC A AU U UU C GUA CU A GIG UUG G G CIG C AC U UC C UG A stop( K tor V( A 5 A UG A AA G CIA A UU UC G UA C UG A AA G GU U GG C GC A CU U CC U GA E)(s)(N)(F)(R)(T)(E)(s)(L)(V)(A)(H Mol. Biol. Gene Fig 14-1 Some phage dNA segments contain overlapping genes in different reading frames(Fig. 32-6) Maximal use of the little dna that they can pack inside their capsids
6. Three possible reading frames Mol. Biol. Gene, Fig. 14-1 Some phage DNA segments contain overlapping genes in different reading frames (Fig. 32-6) Maximal use of the little DNA that they can pack inside their capsids
7. Wobble of the anticodon 摆动假说( wobble hypothesis)是由 Crick.F(1966年)提 出的。即当tRNA的反密码子与mRNA的密码子配对时 前两对严格遵守碱基互补配对法则,但第三对碱基有 定的自由度可以“摆动”。摆动假说也称为三中读 (2 out of3 reading)。 Nucleotide at 5-end Nucleotide at 3 -end of anticodon of codon Can pair with U or c GCAU Can pair with G Can pair with Can pair with Aor g I(inosine) Can pair with AU or C
• 摆动假说(wobble hypothesis)是由Crick.F（1966年）提 出的。即当tRNA的反密码子与mRNA的密码子配对时 前两对严格遵守碱基互补配对法则，但第三对碱基有 一定的自由度可以“摆动” 。摆动假说也称为三中读 二（2 out of 3 reading）。 7. Wobble of the anticodon Nucleotide at 5’-end of anticodon Nucleotide at 3’-end of codon G Can pair with U or C C Can pair with G A Can pair with U U Can pair with A or G I (inosine) Can pair with A, U or C