Networks of biological Signaling pathways 信号传递网络 康滷岐高方远马欣荣
Networks of Biological Signaling Pathways 信号传递网络 康海岐 高方远 马欣荣
、生物体内的信号传递 o 1. The sense of signal transduction intercelluar information exchange regulation of metobolism, on body level o 2. Type of signals ● neuroregulation: neurotransmitter(z酰胆碱胺类E sce ell 氨基酸调节肽类等), neuroregulator chemical signalS: CAMP, Calt, hormone 3. Mechanisms 3.1 32 E reaction(±p) 3.3 E activity 3.4 pr. degradation 3.5 intracelluar messager 3.6 seconder messager
一、生物体内的信号传递 ⚫ 1. The sense of signal transduction： ⚫ intercelluar information exchange,regulation of metobolism, on body level ⚫ 2. Type of signals： ⚫ neuroregulation: neurotransmitter(乙酰胆碱,胺类 ⚫ 氨基酸,调节肽类等),neuroregulator ⚫ chemical signals：cAMP, Ca2+ , hormone， ⚫ 3. Mechanisms: ⚫ 3.1 pr. ←→pr., ⚫ 3.2 E reaction(±p ) ⚫ 3.3 E activity ⚫ 3.4 pr. degradation ⚫ 3.5 intracelluar messager ⚫ 3.6 seconder messager ⚫ E cell
生物体内的信号传递 o 4 Signaling pathways: 4.1Ca2+ 42 CAMP 4.3 tyrosine kinase: EGFR, insulinr 4.4 other pr. kinase cascade: PKC, PKA, PKG 4.5 intracelluar protease cascade o Signal transmission occur 1. Pr.pr. Interaction i1. Enzymatic reaction: tp ll1. Pr Degradation 1111. Production of intracellular messager
一、生物体内的信号传递 ⚫ 4. Signaling pathways： ⚫ 4.1 Ca2+ ⚫ 4.2 cAMP ⚫ 4.3 tyrosine kinase: EGFR,insulinR ⚫ 4.4 other pr. kinase cascade:PKC,PKA,PKG ⚫ 4.5 intracelluar protease cascade ⚫ Signal transmission occur: ⚫ i. Pr.—pr. Interaction ⚫ ii. Enzymatic reaction: ±p ⚫ iii. Pr. Degradation ⚫ iiii. Production of intracellular messager
生物体内的信号传递 o 5. cytoplasm membrane receptor 5.1 neurotransmitter-dependention channel (依赖神经递质的离子通道) nAChR(烟碱型乙酰胆碱受体) GABA(y氨基丁酸) GlyR(甘氨酸受体) o 5.2 receptor connecting to signal transduction protein (G,N protein-second messenger -activate E) mAChR(毒蕈碱型乙酰胆碱受体) adrenergic a-β- receptor(肾上腺素能a--受体) 5.3 growth factor receptor( tyrosine kinase activity) PDGFR(血小板衍生的生长因子受体), EGFR(表皮生长因子受体, insulin r(胰岛素受体)
一、生物体内的信号传递 ⚫ 5. cytoplasm membrane receptor： ⚫ 5.1 neurotransmitter-dependention channel ⚫ (依赖神经递质的离子通道)： ⚫ nAChR(烟碱型乙酰胆碱受体) ⚫ GABA(γ -氨基丁酸) ⚫ GlyR(甘氨酸受体) ⚫ 5.2 receptor connecting to signal transduction protein ⚫ (G,N protein →second messenger →activate E.): ⚫ mAChR(毒蕈碱型乙酰胆碱受体) ⚫ adrenergic α-,β-receptor (肾上腺素能 α-,β-受体) ⚫ 5.3 growth factor receptor(tyrosine kinase activity)： ⚫ PDGFR(血小板衍生的生长因子受体)， ⚫ EGFR(表皮生长因子受体)，insulin R(胰岛素受体)
Peptide signaling in Plants PNAS. NoV 6. 2001. voL.98 no 23 In plants, only a few peptide have been identified that act as signaling molecules e In contrast, signaling peptides are major players in all aspects of the life cycle in animals and yeast suggests that signaling mechanisms across the eukaryotic kingdom are fundamentally different
Peptide Signaling in Plants PNAS, Nov. 6, 2001, vol.98 no. 23 • In plants, only a few peptide have been identified that act as signaling molecules. • In contrast, signaling peptides are major players in all aspects of the life cycle in animals and yeast. • suggests that signaling mechanisms across the eukaryotic kingdom are fundamentally different