急性肾炎抗“0”升高 一急肾炎抗“0”正常 Age 百 肾病综合征 typically affects children 率 aged 5-15 years % 5% are younger than 2 years and 10% are older than 40 ars 年龄岁) 图1急性肾炎与肾病综合征发病年龄分布
Age • typically affects children aged 5-15 years •5% are younger than 2 years and 10% are older than 40 years
1.Etiology ◆β- hemolytic streptococcus, group A antigen components of cytoplasm membrane frequently CIC, sometimes 'planted antigen ◆ Others other bacteria ● viruses parasites
1.Etiology ♦ -hemolytic streptococcus, group A • antigen – components of cytoplasm & membrane – frequently CIC, sometimes ‘planted antigen’ ♦ Others • other bacteria • viruses • parasites
1.Etiology nephritogenic streptococci strains ◆ pyoderma M types47,49,55,2,60,and57 throat infection(pharyngitis) M types 1,2,4,3,25,49,and12
1.Etiology ➢ nephritogenic streptococci strains ♦ pyoderma M types 47, 49, 55, 2, 60, and 57 ♦ throat infection(pharyngitis) M types 1, 2, 4, 3, 25, 49, and 12
2. Pathology Gross examination Swollen with scattered petechia
2. Pathology Gross examination Swollen with scattered petechia
Noma| glomeru山us Post-streptococcal glomerulonephritis enlarged glomeruli relatively bloodless diffuse mesangial cell proliferation Increase in mesangial matrIX
Normal glomerulus Post-streptococcal glomerulonephritis ◼ enlarged glomeruli ◼ relatively bloodless ◼ diffuse mesangial cell proliferation ◼ increase in mesangial matrix