Interaction of cells and extracellular matrix 5 orientation of cytoskeleton in celI O orients he assembly of secreted e> celluar matrix molecules an the vicinity The extracellular c acellUlar matrx reaches cells and orients the matrix propagate order cyto hose cells from cell to cell within a tissue cells (2 and (3 now secrete an oriented matri their vicinity: in this way the ordas cytoskeleton is propagated to ceils and
The extracellular matrix propagate order from cell to cell within a tissue. Interaction of cells and extracellular matrix
Interaction of cells and extracellular matrix extracellular activating signal figand for integrin INTEGRIN ACTIVATION ACTIVATION activated integrin y REGULATION OF MATRIX-BINDING intracellular SITE plasma membrane signaling cascade extracellular matrix INTEGRINS DISSOCLATE FROM ACTIN CORTEX PHOSPHORYLATION AND DISPERSE OF INTEGRINS REGULATION OF CYTOSKELE TAI attachment ATTACHMENT protein engaged integrins at actin cytoskeleton focal contact Cells can regulate the activity of their integrins
Cells can regulate the activity of their integrins Interaction of cells and extracellular matrix
Interaction of cells and extracellular matrix transmembrane heparan fate proteoglycan glycosaminoglycan chair CYTOSOL of the proteoglycan PDGF dimer EXTRACELLULAR FGF bound to SPACE glycosaminoglycan CYTOSOL CYTOSOL target FGF receptors Eph receptors signaling proteins can cross-link receptor chains
Interaction of cells and extracellular matrix signaling proteins can cross-link receptor chains
三民 C/2 COLLEGE OF MEDICINE THIRD MIILITARY MEDICAL UNIVERSITY 2细胞信号转导 Signal transduction CELL- SURFACE RECEPTORS INTRACELLULAR RECEPTORS plasma membrane cell- surface small hydrophobic signaling molecule receptor arrier protei molecule intracellular receptor
THIRD MIILITARY MEDICAL UNIVERSITY COLLEGE OF MEDICINE THIRD MIILITARY MEDICAL UNIVERSITY COLLEGE OF MEDICINE 2.细胞信号转导 Signal transduction
信号转导的基本过程 ligand am Second messenger /Signal transduction cAMP、Ca2+ cascade Gene expression transcription factor/nucleus/chromosome Biologica effect
receptor ligand Second messenger /Signal transduction cascade cAMP、Ca2+ Biological effect 信号转导的基本过程 Gene expression transcription factor/nucleus/chromosome