Overview of cell adhesion Cell adhesion molecules(CAM) Table 19-5 Cell Adhesion Molecule Families SOME FAMILY Ca2+ OR Mg 2+ HOMOPHILIC ORCYTOSKELETON CELL JUNCTION MEMBERS DEPENDENCE HETEROPHILIC ASSOCIATIONS ASSOCIATIONS Cell-Cell Adhesion Classical cadherins E, N, P VE homophilic actin filaments(via adherens junctions, catenins Desmosomal desmoglein, yes homophilic intermediate filaments desmosomes cadherins desmocollin (via desmoplakin, plakoglobin, and plakophilin) Ig family members N-CAM, ICAM no both unknown neuronal and immunological synapses Selectins(blood cells L,E, and heterophilic actin filaments (no prominent junctional and endothelial cells P-selectins only) Integrins on blood cells aLB2(LFA1)yes heterophilic actin filaments immunological synapses Cell-Matrix Adhesion Integrins many types ye heterophilic actin filaments(via focal adhesions talin, paxillin, filamin a-actinin, and vinculin) 4 heterophilic intermediate filaments hemidesmosomes (via plectin and dystonin) Transmembrane syndecans heterophilic actin filaments (no prominent junctional proteoglycans structure) Table 19-5 Molecular Biology of the Cell 5/e(o Garland Science 2008)
Cell adhesion molecules(CAM) Overview of cell adhesion
Selectins, integrins and Ig- super family mediate the cell-cell adhesions basal lamina WEAK ADHESION STRONG ADHESION AND ROLLING AND EMIGRATION selectin-dependent)(integrin-dependent)blood vessel white blood cell endothelial cell tis ssue
Selectins,integrins and Ig-superfamily mediate the cell-cell adhesions
Cell Junction tight junction actIn fiLaments dhesion belt (cadherins) cadherins 8 desmosome (cadherins) Ig-like CAMS integrins inter- mediate gap junction selectins filaments (connexins) hemidesmosome focal contact integral (integrins (integrins membrane proteoglycan integrins basal lamina ↓ JUNCTIONAL ADHESION MECHANISMS NONJUNCTIONAL ADHESION MECHANISMS
Cell Junction
三涅民驾种谓 C/2 COLLEGE OF MEDICINE THIRD MIILITARY MEDICAL UNIVERSITY 1.2 Cell and extracellular matrix Scanning electron micrograph of fibroblasts in connective tissue .o um of their volume is extracellular space, which is large/ r issues are not made up solely of cells. A substantial pa filled by an intricate network of macromolecules constituting the extracellular matrix
THIRD MIILITARY MEDICAL UNIVERSITY COLLEGE OF MEDICINE THIRD MIILITARY MEDICAL UNIVERSITY COLLEGE OF MEDICINE 1.2 Cell and Extracellular Matrix Scanning electron micrograph of fibroblasts in connective tissue. Tissues are not made up solely of cells. A substantial part of their volume is extracellular space, which is largely filled by an intricate network of macromolecules constituting the extracellular matrix
ECM: an intricate network of macromolecules Polysaccharide chain: Glycosaminoglycan(GAG)氨基聚糖 proteoglycan(PG)蛋白聚糖 Fibrous proteins: Collagen(CL), elastin Fibronectin(Fn), laminin(Ln 胶原 纤粘连蛋白 纤粘连 蛋白聚糖 小D MD5 《《福 WD 整联蛋白
ECM: an intricate network of macromolecules . Polysaccharide chain: Glycosaminoglycan (GAG) 氨基聚糖 proteoglycan (PG) 蛋白聚糖 Fibrous proteins: Collagen (CL), elastin Fibronectin (FN), laminin (LN)