Cardiac mechanisms of acetylcholine Na Ach NorEpi Muscaria Beta-1 Receptor Receptor G Stimulates Stimulates Inhibition Cyclic-AMP
Cardiac mechanisms of acetylcholine
Mechanisms of acetylcholine -increase K& decrease Ca permeability K+ outward↑,MRP|↑, phase4 spontaneous depolarization \, autorhythmicity l Inhibition of Caz+ channel, phase 0 amplitude velocity \, conductivity l Ca2+ influx V, [Ca2+]V, contractility t
Mechanisms of acetylcholine —increase K+ & decrease Ca2+ permeability • K+ outward , |MRP| , phase 4 spontaneous depolarization , autorhythmicity • Inhibition of Ca2+ channel, phase 0 amplitude & velocity , conductivity • Ca2+ influx , [Ca2+ ] i , contractility
Cardiac effect of parasympathetic stimulation Parasympathetic stimulation Before vagal stimulation During vagal stimulation ga 八AAA 75 50 且2 八 01 3.4.50.12345 Ime
Cardiac effect of parasympathetic stimulation
Vagal Maneuvers · Valsalva maneuver A maneuver in which a person tries to exhale forcibly with a closed glottis( the windpipe) so that no air exits through the mouth or nose as, for example, in strenuous coughing straining during a bowel movement, or lifting a heavy weight. The Valsalva maneuver impedes the return of venous blood to the heart Named for Antonio maria valsalva. a renowned italian anatomist, pathologist, physician, and surgeon(1666-1723) who first described the maneuver
Vagal Maneuvers • Valsalva maneuver – A maneuver in which a person tries to exhale forcibly with a closed glottis (the windpipe) so that no air exits through the mouth or nose as, for example, in strenuous coughing, straining during a bowel movement, or lifting a heavy weight. The Valsalva maneuver impedes the return of venous blood to the heart. – Named for Antonio Maria Valsalva, a renowned Italian anatomist, pathologist, physician, and surgeon (1666-1723) who first described the maneuver
Diaphragm Abdominal Muscles dominal Cavity Rectal Muscles A VALSALVA MANEUVER