Leukemia 浙江大学血液病研究所 医学院附属一院血液科 金洁
Leukemia 浙江大学血液病研究所 医学院附属一院血液科 金洁
Definition Leukemia is a clonal, malignant disease of hematopoietic tissue that is characterized by O the proliferation of abnormal leukemic cells, principallyin the marrow 2) impaired production of normal blood cells (3) infiltration in tissue and organs Thus, the leukemic cell infiltration in marrow is accompanied nearl invariably by anemia and thrombocytopenia. The absolute neutrophil count may be low or normal, depending on the total white cell count Also, Hepatomegaly, Splenomegaly and lymphopathy because of infiltration in tissue and organs
Definition ⚫ Leukemia is a clonal, malignant disease of hematopoietic tissue that is characterized by: (1) the proliferation of abnormal leukemic cells, principally in the marrow; (2) impaired production of normal blood cells. （3）infiltration in tissue and organs Thus, the leukemic cell infiltration in marrow is accompanied, nearly invariably, by anemia and thrombocytopenia. The absolute neutrophil count may be low or normal, depending on the total white cell count. Also, Hepatomegaly, Splenomegaly and lymphopathy because of infiltration in tissue and organs
Incidence ● about3-4per100.00 o It is more common in males About 181: 1 o AML about 1. 6 per 100,000; ALL about 0.69 per 100,000; CML about 0.39 per 100.000: CLL about0.05per100.000
Incidence ⚫ about 3-4 per 100,000； ⚫ It is more common in males. About 1.81:1. ⚫ AML about 1.6 per 100,000; ALL about 0.69 per 100,000; CML about 0.39 per 100,000; CLL about 0.05 per 100,000
Etiology Virus. hTL-1 o Chemical and drugs: Benzene, Alkylating agents and other cytotoxic drugs ● Radiation o Inherited conditions: Identical sibling with Leukemia: Down syndrome Fanconi anemia ● Double hits
Etiology ⚫ Virus: HTLV-1 ⚫ Chemical and drugs: Benzene, Alkylating agents and other cytotoxic drugs ⚫ Radiation ⚫ Inherited conditions: Identical sibling with Leukemia; Down syndrome; Fanconi anemia ⚫ Double hits
Classification Acute Leukemia: AML. ALL o Chronic Leukemia: CML CLL o Special kind of Leukemia: HCL
Classification： ⚫ Acute Leukemia: AML, ALL ⚫ Chronic Leukemia: CML, CLL ⚫ Special kind of Leukemia: HCL