Cell Signal Transduction and Diseases Jimin shao(邵吉民) Professor, Dept. Pathology and Pathophysiology Tel:88208209 E-mail:shaojimin@zju.edu.cn
Cell Signal Transduction and Diseases Jimin Shao (邵吉民) Professor, Dept. Pathology and Pathophysiology Tel: 88208209 E-mail: shaojimin@zju.edu.cn
1. Introduction: Cell signaling and signal transduction (1) Cell signaling (2) Types of cellular signals (3) Functions 2. Gap junction and diseases (1 Structure of gap junction (2)Function of gap junction (3)Related diseases 3. Receptor-Mediated Signal Transduction and diseases (1)Cell-surface receptors (2)Nuclear receptors B3)Regulatory mechanisms of signal transduction (4)Disorders and related diseases
1. Introduction: Cell signaling and Signal transduction (1) Cell signaling (2) Types of cellular signals (3) Functions 2. Gap junction and diseases (1) Structure of gap junction (2) Function of gap junction (3) Related diseases 3. Receptor-Mediated Signal Transduction and diseases (1) Cell-surface receptors (2) Nuclear receptors (3) Regulatory mechanisms of signal transduction (4) Disorders and related diseases
Introduction: Cell signaling and signal transduction 1. Cell Signaling (1) Direct Intercellular Communication Gap Junction magnet ◆ Gap Junction (2)Signaling by plasma-membrane bound molecules (3) Receptor-Mediated Intercellular communication Cell-Surface Receptors ◆ Nuclear Receptors SIGNALING BY PLASMA-MEMBRANE-BOUND MOLECULES SIGNALING BY SECRETED MOLECULES SIGNALING TARGET SIGNALING TARGET CELL CELL CELL CELI signaling molecu鲁 receptor molecule
Introduction: Cell signaling and Signal transduction 1. Cell Signaling (1) Direct Intercellular Communication ◆Gap Junction (2) Signaling by plasma-membrane bound molecules (3) Receptor-Mediated Intercellular communication ◆Cell-Surface Receptors ◆Nuclear Receptors Gap Junction
pes of cellular signals (1) Chemical signals Hormones, neurotransmitters, growth factors, cytokines odor molecules; ATP, active oxygen; drugs, toxins, etc 2)Physical signals Light, electronic, mechanic, UV, heat, volume, osmotic, etc
2. Types of cellular signals (1) Chemical signals Hormones, neurotransmitters, growth factors, cytokines; odor molecules; ATP, active oxygen; drugs, toxins, etc (2) Physical signals Light, electronic, mechanic, UV, heat, volume, osmotic, etc
(3) Modes for the function of endogenous signals Endocrine Act on a far away organ via blood circulation, seen in most hormones Paracrine ct on a nearby target, seen in GFs, CKs, etc Synaptic: Presynaptic to postsynaptic(neurotransmitters Autocrine Act on itself after secreted, seen in GFs, especially in tumor tissues Intracrine Act on itself before secreted, seen in nuclear receptors
Endocrine Act on a far away organ via blood circulation, seen in most hormones Paracrine Act on a nearby target, seen in GFs, CKs, etc Synaptic: Presynaptic to postsynaptic (neurotransmitters) Autocrine Act on itself after secreted, seen in GFs, especially in tumor tissues Intracrine Act on itself before secreted, seen in nuclear receptors (3) Modes for the function of endogenous signals