Fluid mosaic model for membrane structure (based on EM, chemical composition permeability, motions of lipids and proteins) oligosaccharide chains of Glycolipid Outside Phospholipid polar heads Sterol Inside Peripheral protein e6 Integral protein Peripheral protein Integral protein (single trans- covalently linked (multiple trans- The fatty acyl chains in the interior of the membrane form a fluid to lipid brane helices) drophobic region. Integral proteins float in this sea of lipid, held by hydrophobic interactions with their nonpolar amino acid side chains. Both proteins and lipids are free to move laterally in the plane of the bilayer, but movement of either from one face to the other is restricted
Fluid Mosaic Model for Membrane Structure (based on EM, chemical composition, permeability, motions of lipids and proteins) The fatty acyl chains in the interior of the membrane form a fluid, hydrophobic region. Integral proteins float in this sea of lipid, held by hydrophobic interactions with their nonpolar amino acid side chains. Both proteins and lipids are free to move laterally in the plane of the bilayer, but movement of either from one face to the other is restricted
Mosaic-proteins are embedded at irregular intervals (asymmetric, sidedness) Fluid--noncovalent interactions oligosaccharide chains of glycoprotei Glycolipid Outside Nonp fatty acyl bilayer Phospholipid 35880 bolar heads Sterol Inside Peripheral Integral protei Peripheral protein Integral protein (single trans- covalently linked nultiple trans- membrane helix) to lipid membrane helices) What are the experimental evidence supporting this model?
Mosaic—proteins are embedded at irregular intervals (asymmetric, sidedness) Fluid—noncovalent interactions What are the experimental evidence supporting this model?
a lipid bilayer is the basic structural element of membranes glycerophospholipids sphingolipids Lipid aggregates --sterols (thermodynamically stable) --water
A lipid bilayer is the basic structural element of membranes --glycerophospholipids --sphingolipids --sterols --water Lipid aggregates (thermodynamically stable)