Cell Signaling General Principles of Cell Signaling 三、 Signaling mediated by Intracellular Receptors Signaling Mediated by Cell-Surface Receptors
Cell Signaling 一、General Principles of Cell Signaling 二、Signaling Mediated by Intracellular Receptors 三、Signaling Mediated by Cell-Surface Receptors
Grey boxes: general components of signaling pathways factor bindir domain White boxes: specific examples Receptor gan Cell kinas membrane Receptors Enzymatic intracellular Altered domain metabolism Protein kinase activity Intracellular mediators messengers (cytoplasmic molecul Adaptor protei Docking proteins Nuclear events Effector GTP-binding proteins enzymes Other Protein or lipid kinases phosphodiesterases Metabolic enzymes Transcription factors Nucleus Nature 411: 759(2001) Changes in Nuclear membrane gene expression
Grey boxes: general components of signaling pathways White boxes: specific examples Ligand Receptors Intracellular mediators Nuclear events Nature 411: 759 (2001)
Cell Signaling General Principles of Cell Signaling 三、 Signaling mediated by Intracellular Receptors Signaling Mediated by Cell-Surface Receptors 1.lon-Channel-Linked Receptors
Cell Signaling 一、General Principles of Cell Signaling 二、Signaling Mediated by Intracellular Receptors 三、Signaling Mediated by Cell-Surface Receptors 1. Ion-Channel-Linked Receptors
OO coo Subunit folds into four MI M2 M1 M2 M8 M4 Acetylcholine binding sites y Outside M1 M4 M2 M3 (B, 1, 8 are homologous Inside M2 amphipathic helices
acetylcholine bindin site lipid channel bilayer ore 4 nm CYTOSOL gate A Model for the structure of the nicotinic(烟碱型) Acetylcholine Receptor Five homologous subunits combine to form a transmembrane aqueous pore. n its closed conformation, the pore is thought to be occluded by the hydrophobic side chain of five leucine residues which form a gate near the middle of the lipid bilayer
A Model for the Structure of the Nicotinic(烟碱型) Acetylcholine Receptor Five homologous subunits combine to form a transmembrane aqueous pore. In its closed conformation, the pore is thought to be occluded by the hydrophobic side chain of five leucine residues which form a gate near the middle of the lipid bilayer