Catalysts Do Not Affect ReactionEquilibriaanyenzymethatcatalyzesthereactionS-PalsocatalyzesthereactionP→Senzymes accelerate the interconversion of S and Penzymesarenotusedupintheprocess.theequilibriumpointisunaffected
NoncovalentInteractionsbetweenEnzymeandSubstrate Are Optimized in the Transition State"lockandkey"hypothesis=enzymesarestructurallycomplementarytotheirsubstratesTetrahydr
The Active Site of an Enzymeoptimized binding energyinthetransitionstateisaccomplished by positioning a substrate in a cavity (theactivesite),removedfromH,O
Enzyme Specificityspecificity= ability to discriminate between a substrateandacompetingmolecule-given by binding energy
The Induced Fit Mechanisminducedfit=mechanismbywhichtheenzymeitselfundergoesaconformational changewhenthe substratebinds,inducedbymultipleweak interactions withthesubstrateenhancescatalyticproperties