NH3 clearance↓ NH3 production T Severe hepatic dysfunction Hyperammonemia HE
NH3 production NH3 clearance Severe hepatic dysfunction HE Hyperammonemia
Causes (1) urea synthesis y ammonia clearance↓ ●ATP o enzyme↓ urea↓;NH2↑ ● substance↓
(1) urea synthesis ↓,ammonmia clearance ↓ • ATP ↓ • enzyme ↓ • substance ↓ urea ↓; NH3↑ Causes
Production of urea 2NH3+4ATP→1urea 尿素 鸟氨酸 NH:+ cO H20 H20精氨酸酶 瓜氨酸 HoO TNH 所氨酸
Production of urea: 2NH3+4ATP→1 urea
(2) production of ammonia A mucosa edema bacterium hemorrhage Intes. amino acid Renal dys Intestinal urea NH3 function Activity of Acetylic acid muscle decompose Urine ph intestinal
(2) production of ammonia↑ mucosa edema bacterium Intes. amino acid Renal dys -function Activity of muscle Acetylic acid decompose Intestinal urea pH NH3 Urine intestinal hemorrhage
血液肾小管上皮细胞人 NH 3 NH+ 酸中泰射
血液 肾小管上皮细胞 管腔 NH3 H+ NH4 + 酸中毒时