山东大学基础医学院：《病理生理学 Pathophysiology》课程PPT教学课件（7年制）12 hepatic insufficiency 肝衰竭（肝功能不全）

Function of the liver gestion excretion synthesizing detoxification metabolic immune

Function of the liver ◼ Digestion ◼ excretion ◼ synthesizing ◼ detoxification ◼ metabolic ◼ immune

Causes of liver disease Biological Factors Physical and chemical Factors Genetic Factors Immunity Factors Nutritional Factors:

Causes of Liver Disease – Biological Factors: – Physical and Chemical Factors: – Genetic Factors: – Immunity Factors: – Nutritional Factors:

Hepatic insufficiency Jaundice bleeding Severe Causes infection damage in liver cells renal dysfunction encephalopathy hepatic failure

Hepatic insufficiency Jaundice Bleeding infection renal dysfunction encephalopathy Severe damage in liver cells hepatic failure Causes

hepatic encephalopathy Neuropsychiatric symptoms occuring in patients with severe liver diseases are usually summarized as hepatic encephalopathy (He)

Neuropsychiatric symptoms occuring in patients with severe liver diseases are usually summarized as hepatic encephalopathy (HE) hepatic encephalopathy

Classification Endogenous HE 25%o Fulminant hepatic failure Exogenous HE 75% Portal-systemic encephalopathy Plasma level of ammonia

Endogenous HE 25% Fulminant hepatic failure Exogenous HE 75% Portal-systemic encephalopathy Plasma level of ammonia↑ Classification