Pathogenesis Renin-angiotensin-aldosterone system Vascular endothelial growth factor ·Prostaglandin Vascular permeability factor 6
Pathogenesis • Renin-angiotensin-aldosterone system • Vascular endothelial growth factor • Prostaglandin • Vascular permeability factor 6
Renin-angiotensin-aldosterone System HCG made prorenin increase Prorenin transformed to renin Activation of the renin -angiotensin-aldosterone system Angiotensin ll affected the angiogenesis and increased the permeability of capillaries 7
Renin-angiotensin-aldosterone System • HCG made prorenin increase . Prorenin transformed to renin • Activation of the renin - angiotensin- aldosterone system • Angiotensin II affected the angiogenesis and increased the permeability of capillaries 7
Vascular Endothelial Growth Factor VEGF is the one of the major factors High level of estrogen and HCG induced the synthesis of VEGF High level of VEGF promoted the proliferation of vascular endothelial cell and increased the permeability of capillary 8
Vascular Endothelial Growth Factor • VEGF is the one of the major factors • High level of estrogen and HCG induced the synthesis of VEGF • High level of VEGF promoted the proliferation of vascular endothelial cell and increased the permeability of capillary 8
Prostaglandin High level of estrogen and HCG activiated arachidonic acid.Arachidonic acid transformed to epoxidase Promoted prostaglandin secretion ·Histamine increased Increased the permeability of capillary Hydrothorax and ascite 9
Prostaglandin • High level of estrogen and HCG activiated arachidonic acid. Arachidonic acid transformed to epoxidase • Promoted prostaglandin secretion • Histamine increased • Increased the permeability of capillary • Hydrothorax and ascite 9
Vascular Permeability Factor mRNA expression of vascular permeability factor increase in granular cell is related to COH Cytokines increased,including TNF,IL-1 and IL-2 Some of mediators of inflammation increased. including histamine and serotonin,which damaged the capillary and reduced angiotelectasis 10
Vascular Permeability Factor • mRNA expression of vascular permeability factor increase in granular cell is related to COH • Cytokines increased, including TNF, IL-1 and IL-2 • Some of mediators of inflammation increased, including histamine and serotonin,which damaged the capillary and reduced angiotelectasis 10