H.pylori infectionSpiralbacteriaAftermonthsNon-invasivebacteriaChronicsuperficialgastritisChronicinflammationAfteryearsHyperacidityChronicgastricatrophyLymphoproliferativedisorders→4B-celllymphomaPepticulcerdiseaseGastric carcinoma3-6times6-50times2-8timesBAFIGURE18.7A,Histologic appearance of H.pylori chronic gastritis.B,Consequences oflong-termH.pylori gastritis
() chronic superficial gastritis (CSG)commonglands in lamina propria intact,lymphocyte/plasma infiltrate in shallow mucosa
(1) chronic superficial gastritis (CSG) common glands in lamina propria intact, lymphocyte/plasma infiltrate in shallow mucosa
(CAG)(2)chronicatrophicgastritismucosa thin, folds flattengross:LMwithin mucosa: lymphocyte, plasma cells infiltrate,aggregate, lymph follicle formmucosal proper glands (gastricglands,cardiacglands, pyloric glands)atrophy or disappear, dilateintestinalofmetaplasia(replacementgastriccellsofwith columnarepitheliumandgobletintestinal-type), pseudopyloricmetaplasia
(2) chronic atrophic gastritis (CAG) gross：mucosa thin, folds flatten LM within mucosa: lymphocyte, plasma cells infiltrate, aggregate, lymph follicle form mucosal proper glands (gastric glands,cardiac glands, pyloric glands）atrophy or disappear, dilate intestinal metaplasia (replacement of gastric epithelium with columnar and goblet cells of intestinal-type), pseudopyloric metaplasia
chronic atrophic gastritis (CAG)loss of rugal folds in thebody and fundus
chronic atrophic gastritis (CAG) loss of rugal folds in the body and fundus
时一25正常粘核人和经抢（B）中度（心）以及最度（D）使生美拍性价英的全角见，所存这共活铃标本5为数年首川使式置运本H人表