Section 2 Etiology · Infectious factors Noninfectious factors
Section 2 Etiology • Infectious factors • Noninfectious factors
Infective fever Metabolites( pyrogens)from microorganism Most common causes(50%0-60% ● Bacteria:(43%) Viral pyrogens: (6%)
Infective fever •Metabolites( pyrogens) from microorganism Most common causes (50%~60%) •Bacteria : (43%) •Viral pyrogens: (6%)
Non-infective fever Absorption of necrotic substances: cell necrosis . Allergy: Antibiotics (Ag Ab+c)
Non-infective fever •Absorption of necrotic substances: cell necrosis •Allergy：Antibiotics (Ag + Ab + C)
Section 3 Pathogenesis of fever Pyrogens: Substances that can cause ever Either exogenous or endogenous(EP
Section 3 Pathogenesis of fever • Pyrogens: Substances that can cause fever • Either exogenous ~ or endogenous ~(EP)
1. Exogenous Pyrogens (1)From outside the host majority are microorganism G: endotoxin LPS G+: lipoteichoic acid peptidoglycan
1. Exogenous Pyrogens (1)From outside the host Majority are microorganism G- : endotoxin (LPS) G+ : lipoteichoic acid peptidoglycan