Lecture16Cellular Cooperation and AntigenRecognitionS
Lecture 16 Cellular Cooperation and Antigen Recognition
Cellular CooperationantigenPlasma CellsAntigen presentation toTand B cells byAPCT cells elaborate cytokines toAntibodysecretion byfacilitate B cell proliferationAntigen presenting cellplasma cellsand maturation
Cellular Cooperation TH B antigen Antibody secretion by plasma cells Plasma Cells Antigen presenting cell Antigen presentation to T and B cells by APC T cells elaborate cytokines to facilitate B cell proliferation and maturation
AntigenPresenting CellsMustbe capable of processing antigen fromextracellular andintracellular pathogensMustpresentprocessed antigenonMHC classI&IImoleculesMustexpress co-stimulatory molecules (cytokines)
Antigen Presenting Cells ◼ Must be capable of processing antigen from extracellular and intracellular pathogens ◼ Must present processed antigen on MHC class I & II molecules ◼ Must express co-stimulatory molecules (cytokines)
Types of ProfessionalAntigenPresenting CellsMacrophages/monocytesDendritic cells (e.g.., Langerhan's cells)Bcells
Types of Professional Antigen Presenting Cells ◼ Macrophages/monocytes ◼ Dendritic cells (e.g., Langerhan’s cells) ◼ B cells
MacrophagesDendritic cellsBcellsPropertiesofProfessionalHC5Antigen-Presenting+++PhagocytosisbyAntigen-specificAntigenPhagocytosisCellstissue dendritic cells.reepior (g)uptake+++++++Viral infection++IndudblebyConstitutiveMHCConstitLtivebacteriaand cytokinesIncreasesonactivationexpression++-to ++++++to++++Constitutive,bymatureCo-stimulatorIndudbleInducblenon-phagocyicMmphoiddeivery-to +++dendrtc cells-to++++++Partiaulate antigens.PeptdesSolubie antigens.ArntigenViral antigensIntracellLlar andToxins.presentedextracellularpathogens(allergens?)VinusesLymphoid fissue.Lymphoid tissue.LymphoidtissueConnectivefissueLocationConnedivetissuePeripheral bloodBodycavitiesEpithelia@1997CurrentBiologyLtd./GarlandPublishing.Inc
Properties of Professional AntigenPresenting Cells