Anti-infectives A∥ rights re served Chemotherapeutic Agents Anticancer Antiparasite Anti-infectives MP士海医药工业研究院 NDUSTRY
Anti-infectives All rights re served Chemotherapeutic Agents ▪ Anticancer ▪ Antiparasite ▪ Anti-infectives
Anti-infectives A∥ rights re served Totally Synthesized Antibacterials sulfonamides and the synerists fluoroquinolones oxazolidinones嵁唑烷酮类 MP士海医药工业研究院 NDUSTRY
Anti-infectives All rights re served Totally Synthesized Antibacterials ▪ sulfonamides and the synerists ▪ fluoroquinolones ▪ oxazolidinones噁唑烷酮类
Anti-infectives A∥ rights re served Fluoroquinolone antibacterials Discovery history Marketed products Action mechanism Structure-activity and structure toxicity relationships New progress Synthesis MP士海医药工业研究院 NDUSTRY
Anti-infectives All rights re served Fluoroquinolone antibacterials ▪ Discovery history ▪ Marketed products ▪ Action mechanism ▪ Structure-activity and structuretoxicity relationships ▪ New progress ▪ Synthesis
Anti-infectives A∥ rights re served Discovery history CH3 NHCH(CH2)3N(C2H5)2 CO,H Structural modification H3C C2h4 chloroquine nalidixic acid malarial O CO,H CO,H HN N C2H norfloxacin pipemidIc acid generation 2 generation 3 MP士海医药工业研究院 NDUSTRY
Anti-infectives All rights re served Discovery history N NHCH(CH2 )3N(C2H5 )2 CH3 Cl Structural modification N N C2H5 CO2H O H3C chloroquine antimalarial nalidixic acid N N N O CO2H C2H5 HN N N O CO2H C2H5 HN N F generation 1 pipemidic acid generation 2 norfloxacin generation 3
Anti-infectives A∥ rights re served Marketed products 19个:诺氟沙星,培氟沙星,环丙沙星, 氧氟沙星,依诺沙星,洛美沙星,托氟沙 星,氟罗沙星,卢氟沙星,那氟沙星,左 氟沙星,司氟沙星,曲伐沙星,加替沙星 莫西沙星,帕珠沙星,吉米沙星,巴洛 沙星,普利沙星 兽药6个:达诺沙星,二氟沙星,恩氟沙 星,麻保沙星,奥比沙星和沙拉沙星 MP士海医药工业研究院 NDUSTRY
Anti-infectives All rights re served Marketed products ▪ 19个：诺氟沙星，培氟沙星，环丙沙星， 氧氟沙星，依诺沙星，洛美沙星，托氟沙 星，氟罗沙星，卢氟沙星，那氟沙星，左 氟沙星，司氟沙星，曲伐沙星，加替沙星 ，莫西沙星，帕珠沙星，吉米沙星，巴洛 沙星，普利沙星 ▪ 兽药6个：达诺沙星，二氟沙星，恩氟沙 星，麻保沙星，奥比沙星 和沙拉沙星