讨论(二) 5。帕金森氏症的病因? 6。老年性痴呆症的病因? ■7。舞蹈病的病因? ■8。估计桑兰的病是脊髓何处折断?理由 是什么? ■研究学习和记忆(神经生物学和生理学) 的历史和进展?
讨论（二） ◼ 5。帕金森氏症的病因？ ◼ 6。老年性痴呆症的病因？ ◼ 7。舞蹈病的病因？ ◼ 8。估计桑兰的病是脊髓何处折断？理由 是什么？ ◼ 研究学习和记忆（神经生物学和生理学） 的历史和进展？
Learning and memory Xu Yaozhong School of life sciences
Learning and memory Xu Yaozhong School of Life Sciences
LEARNING AND MEMORY Definition: Learning-the ability to act according to past experience-provides the basis for virtually all cognitive functions, Effective learning requires storage of memories of external (or internal) events in a readily retrievable form
CELLULAR BASIS OF LEARNING As first suggested by D. HEBB Repeated activity of given synaptic connection+ long-lasting, selective increase in efficacy of that synapse THREE KINDS OF POST-ACTIVITY POTENTIATION repetitive stimulation can elicit 1. Post-tetanic potentiation (for 1-4 minutes) 2. Short-lasting potentiation (for 20-30 minutes) 3. Long-term potentiation(for many hours, days, even weeks)
Two kinds of long-term memory EXPLICIT IMPLICIT [FACTS EVENTS] Procedural Nonassociative Skills Associative [Habituation Processed by temporal cortex hippocampus Operant Conditioned Emotional Stored in: Association cortex Striatum Cerebellum Amygdala Reflexes