Outlines History of Drug Discovery New drug development and clinical trials Chemotherapy Development Targeted Agents and New Directions in Drug Development Clinical Uses of Systemic Therapy Systemic Therapy Process
Outlines • History of Drug Discovery • New drug development and clinical trials • Chemotherapy Development • Targeted Agents and New Directions in Drug Development • Clinical Uses of Systemic Therapy • Systemic Therapy Process
Chemotherapeutic Agents Alkylating Agents Platinum Compounds Antimetabolites Purine Analogs Adenosine Analogs Topoisomerase I Inhibitors Antitumor antibiotics Plant alkaloids
Chemotherapeutic Agents • Alkylating Agents • Platinum Compounds • Antimetabolites • Purine Analogs • Adenosine Analogs • Topoisomerase I Inhibitors • Antitumor Antibiotics • Plant Alkaloids
Anthracycline Effective in many tumors: LS, BC, STS Side effects Bone marrow suppression Cardiac toxicity Doxorubicin Epirubicin Pegylated liposome doxorubicin
Anthracycline • Effective in many tumors: LS, BC, STS… • Side effects: – Bone marrow suppression – Cardiac toxicity • Doxorubicin Epirubicin Pegylated liposome doxorubicin
Taxane Effective in many tumors bC, LU, StS Side effects Bone marrow suppression Hypersensitivity, Neuropathy Paclitaxel Docetaxel Albumin bound paclitaxe
Taxane • Effective in many tumors: BC, LU, STS… • Side effects – Bone marrow suppression – Hypersensitivity, Neuropathy • Paclitaxel Docetaxel Albumin bound paclitaxel
Platinum Effective in many tumors: LU, BC, CRc Side effects Bone marrow suppression Neuropathy, Renal function impairment Cisplatin Carboplatin Oxaliplatin
Platinum • Effective in many tumors: LU, BC, CRC… • Side effects – Bone marrow suppression – Neuropathy, Renal function impairment • Cisplatin Carboplatin Oxaliplatin