UNIV 7vhed according to pathological changed ◆ Tuberculoid leprosy Lepromatous leprosy ◆ Borderline leprosy Indeterminate leprosy
Types according to pathological changes Tuberculoid leprosy Lepromatous leprosy Borderline leprosy Indeterminate leprosy
UNIV wh的wy0,m% Intact cellular immune response Slow course, spanning decades imited lesions Few bacilli within the lesion Mainly involve skin and nerves Clinical feature: lepromin test(+) low infectivity good prognosis
Tuberculoid leprosy (60-70%) Intact cellular immune response Slow course, spanning decades Limited lesions Few bacilli within the lesion Mainly involve skin and nerves Clinical feature: lepromin test (+) low infectivity good prognosis
UNIV Tabexylailesnady Granuloma similar to hard tubercles I. epithelioid macrophages 2. giant cells 3. without caseous necrosis 4. Peripheral: CD4* Thl-+IL-2 and IFN-Y 5. few surviving mycobacteria
Tuberculoid leprosy Granuloma similar to hard tubercles 1. epithelioid macrophages 2. giant cells 3. without caseous necrosis 4. Peripheral: CD4+ Th1 IL-2 and IFN-γ 5. few surviving mycobacteria
UNIV Taberawlaidlesnady Skin lesions: macula or papula gross: flat and red irregular shapes with indurated, elevated, hyperpigmented margins and depressed pale centers
Tuberculoid leprosy Skin lesions: macula or papula gross: flat and red irregular shapes with indurated, elevated, hyperpigmented margins and depressed pale centers
UNIV Tabeuawloidlesnady S sIens LM: tuberculoid granuloma enclose blood vessles, cutaneous appendages ana nerves extend to the basal cells ofepidermis
Tuberculoid leprosy Skin lesions LM: tuberculoid granuloma enclose blood vessles , cutaneous appendages and nerves extend to the basal cells of epidermis