Fudan University Shanghai cancer Center Philadelphia(Ph) chromosome Normal normal Chromosome break 9+ Ph BCR 0一目目一目A ABL 22 复旦大学上海医学院肿瘤学糸
Fudan University Shanghai Cancer Center 复旦大学上海医学院肿瘤学系 11 Philadelphia (Ph) Chromosome
Fudan University Shanghai cancer Center Signal-Transduction Pathways Affected by bcr-abl BCR-ABL BCR-ABL T315 Imatinib GRB2 JAK2)(CRKL→(P13K) FAK Actin SOS Cytoskeletal protein C-MYC AKT Paxillin Tallin RAS STATS BAD BAD Adhesion/ migration Transformation Proliferation urviva Apoptosis 12 复旦大学上海医学院肿瘤学糸
Fudan University Shanghai Cancer Center 复旦大学上海医学院肿瘤学系 12 Signal-Transduction Pathways Affected by BCR-ABL
Fudan University Shanghai cancer Center Clinical Course of cml Chronic phase Advanced phases Accelerated phase Blastic phase(blast crisis Median 4-6 years stabilization Median duration up Median survival to 1 year 3-6 months Figure 2 Clinical course of chronic myelogenous leukaemia 13 复旦大学上海医学院肿瘤学糸
Fudan University Shanghai Cancer Center 复旦大学上海医学院肿瘤学系 13 Clinical Course of CML
Fudan University Shanghai cancer Center Development of Treatments for CML Palliative therapy Curative therapy Arsenic Spleen irradiation Busulfan Hydroxyurea Stem cell transplantation Combination chemotherapy Interferon alpha Imatinib Dasatinib, nilotinib 18651903 19531964 1975 1983 19992005 14 复旦大学上海医学院肿瘤学糸
Fudan University Shanghai Cancer Center 复旦大学上海医学院肿瘤学系 14 Development of Treatments for CML
Fudan University Shanghai cancer Center Imatinib Mesylate(Glivec) Imatinib mesylate N O·CH2SO Molecular weight, 589.7 Formula, C30H35N7SO4 15 复旦大学上海医学院肿瘤学糸
Fudan University Shanghai Cancer Center 复旦大学上海医学院肿瘤学系 15 Imatinib Mesylate (Glivec)