Virulence factors No spore no flagellum, no exotoxin, no endotoxin, no invasive enzyme Capsule: polysaccharide; CR3; enzyme; protect ipid/Lipo arabinomannan Heat-shock protein/Tuberculin protein: antigenicity, old tuberculin; associate with wax D can cause hypersensitivity and form tubercle
Virulence factors No spore, no flagellum, no exotoxin,no endotoxin, no invasive enzyme Capsule:polysaccharide;CR3;enzyme; protect Lipid/Lipo arabinomannan Heat-shock protein/Tuberculin protein: antigenicity, old tuberculin; associate with wax D can cause hypersensitivity and form tubercle
Lipid Lipid: closely related to virulence a Phospholipid monocytes proliferate, cause tubercles b Wax D adjuvent(not only to TB), delayed-type hypersensitivity c. Sulfatide硫酸脑苷脂 suppress phagosome combine with lysosome d Cord factor(trehalose-6, 6-dimycolate) destroy mitochondria, cause chronic granulomatosis, suppress wBC wandering
Lipid Lipid: closely related to virulence a. Phospholipid monocytes proliferate,cause tubercles b. Wax D adjuvent(not only to TB), delayed-type hypersensitivity c. Sulfatide硫酸脑苷脂 suppress phagosome combine with lysosome d. Cord factor (trehalose-6,6-dimycolate) destroy mitochondria, cause chronic granulomatosis, suppress WBC wandering
Pathogenesis primary infection D)lung infection secondary infection 2)Out lung infection
Pathogenesis primary infection 1) lung infection secondary infection 2) Out lung infection