4s -Study CAD Mortality per Quartiles of Increases in HDL-Cholesterol 12 10 o28 86420 HDL Placebo Q1 Q2 Q3 Q4 LDL (low HDL-increase) (high HDL-increase) KJEKSHUS J& PEDERSEN T(unpublished)
12 10 8 6 4 2 0 % Mortality Placebo Q1 Q2 Q3 Q4 (low HDL-increase) (high HDL-increase) 4S - Study CAD Mortality per Quartiles of Increases in HDL-Cholesterol KJEKSHUS J & PEDERSEN T (unpublished)
HDL Intervention Trial (VA-HIT Cholesterol LDL-C HDL-c Triglycerides 10 5 oEoo 5 器。-10 so 15 Secondary Prevention in 2531 men with low HDL-C LDL-C showed a 20 22 reduction in combined fatal and non-fatal MI n-25 -30 31 HDL -35 LDL RUBINS HB et al. New Eng/J Med 1999: 341. 410
HDL Intervention Trial (VA-HIT) RUBINS HB et al. New Engl J Med 1999; 341:410 0 6 -31 -4 -35 -30 -25 -20 -15 -10 -5 0 5 10 Cholesterol LDL-C HDL-C Triglycerides Percent change compared to placebo at 1 year Secondary Prevention in 2531 men with low HDL-C & LDL-C showed a 22% reduction in combined fatal and non-fatal MI
HDL- Cholesterol as Risk Factor for CHD LRC-CPPT(Placebo) MRFIT(usual care) Incidence rate of chd Incidence rate of chd 12 HDL-C 10 [mg /dl 8 8 65 55 6 6 45 35 4 2 0 100130160190 100130160190 LDL-Cholesterol mg /dl LDL-Cholesterol mg /dl HDL LDL GORDON DJet al. circulation 1989: 79: 8-15
HDL - Cholesterol as Risk Factor for CHD LRC - CPPT (Placebo) MRFIT (usual care) Incidence rate of CHD Incidence rate of CHD 12 10 8 6 4 2 0 100 130 160 190 GORDON DJ et al. Circulation 1989; 79: 8 - 15. HDL - C [mg / dl] 65 55 45 35 LDL - Cholesterol mg / dl LDL - Cholesterol mg / dl 12 10 8 6 4 2 0 100 130 160 190
Framingham Heart Study CAD risk as a function of ldl-C and HDL-c in men (50 to 70 y) 2.5 1.5 25 0.5 65 85 160 HDL 220 100 LDL Cholesterol(mg/dL) LDL CASTELL/WP Am J Cardio/: 82: 60-65
0 0.5 1 1.5 2 2.5 3 Framingham Heart Study CAD risk as a function of LDL-C and HDL-C in men (50 to 70 y) CASTELLI WP. Am J Cardiol 1998; 82:60-65 220 160 100 85 65 45 25 LDL Cholesterol (mg/dL)
Helsinki Heart Study Incidence for cardiac events vs lipid parameter Gemfibrozil■ Placebo LDL-C Tertiles(mmol/L)HDL-C Tertiles(mmol/L) LDL-C/HDL-C Tertiles 16 后14 总12 10 888 6 S O 4 224463236 3445223 385 1829 0 LDL<=5 LDL>5 HDL>=1.08 HDL<1.08 LDL/HDL<=5 LDL/HDL>5 LDL MANNINEN V Leena T Koskinen Pet al. Circulation 1992: 85: 37-45
0 2 4 6 8 10 12 14 16 LDL<=5 LDL>5 HDL>=1.08 HDL<1.08 LDL/HDL<=5 LDL/HDL>5 Incidence of cardiac events (per 1000 person -years) Gemfibrozil Placebo LDL-C Tertiles (mmol/L) HDL-C Tertiles (mmol/L) LDL-C/HDL-C Tertiles 24 46 32 36 34 45 22 39 38 53 18 29 Incidence for cardiac events vs lipid parameter Helsinki Heart Study MANNINEN V, Leena T, Koskinen P et al. Circulation 1992; 85: 37-45