血小板内皮损伤，胶原暴露，血小板与胶原粘附脱颗粒（ADP,5-HTvWF血小板释放颗粒合成TXA2纤维蛋白血小板被激活并相互凝集白细胞血小板聚堆红细胞纤维蛋白网释放凝血酶激活纤维蛋白原纤维蛋白网罗白细胞和红细胞，形成血栓
3. The common disease(l) Endocardialinjury:myocardialinfarction,valvulitis(2)Vascularinjury:traumatic,As →ulcerated plaquesinflammatory injury (vasculitis),(3)Hypoxia,shock,bacterialendotoxin→ DIC →microthrombus
3. The common disease (1) Endocardial injury: myocardial infarction, valvulitis (2) Vascular injury: traumatic, As →ulcerated plaques inflammatory injury (vasculitis), (3) Hypoxia, shock, bacterial endotoxin → DIC →microthrombus
(二)Alteration in normal blood flow1. Refer to Stasis or turbulence()Disruptlaminarflow andbring platelets intocontact with EC.(2)Prevent dilution byfresh flowing blood ofactivated clottingfactors(3)Retard theinflow of clottingfactor inhibitorsand permit the build-up of thrombi(4) Promote EC activation, predisposing to localthrombosis,leukocyte adhesion
(二) Alteration in normal blood flow 1. Refer to Stasis or turbulence (1) Disrupt laminar flow and bring platelets into contact with EC . (2) Prevent dilution by fresh flowing blood of activated clotting factors (3) Retard the inflow of clotting factor inhibitors and permit the build-up of thrombi (4) Promote EC activation, predisposing to local thrombosis, leukocyte adhesion
2. Vein is the favored sites :) Venous valves→slow,turbulence2)Fugaciousstasis3)Thinnerwall→pressedeasily4)Adherenceincreased(blood from capillary→Vein)
2. Vein is the favored sites : 1) Venous valves →slow, turbulence 2) Fugacious stasis 3) Thinner wall →pressed easily 4) Adherence increased (blood from capillary →Vein)
(三）Hypercoagulability1.Inherited causes of hypercoagulability:(1) The most common cause:Mutations in the factor Vgeneprothrombin gene(2)Inheritedlackof theanticoagulants:anti-thrombinprotein C, protein S
(三) Hypercoagulability 1. Inherited causes of hypercoagulability: (1) The most common cause: Mutations in the factor V gene prothrombin gene (2) Inherited lack of the anticoagulants: anti-thrombin protein C, protein S