一.Conditions and mechanismof thrombosisThree primary influences predispose tothrombus formation:()Endothelialinjury(2)Alterationinnormalbloodflowstasis or turbulence of blood flow(3)Bloodhypercoagulability
一 .Conditions and mechanism of thrombosis Three primary influences predispose to thrombus formation: (1) Endothelial injury (2) Alteration in normal blood flow stasis or turbulence of blood flow (3) Blood hypercoagulability
(一) Endothelial injuryNormal condition:IntactECinhibitcplateletadherenceblood clotting·Injury or activated EC augmentslocalbloodclotting
(一) Endothelial injury Normal condition: Intact EC inhibit platelet adherence blood clotting. Injury or activated EC augments local blood clotting
1.Functions of Endothelium(1).AntithromboticpropertiesDScreenfunction ofintact endotheliumAntiplateletadheringAnticoagulantsFibrinolytic
1. Functions of Endothelium (1). Antithrombotic properties ① Screen function of intact endothelium ② Antiplatelet adhering ③ Anticoagulants ④ Fibrinolytic
抑制血小板凝集灭活激活V蛋白C个Va、Vila内皮细胞抑制血栓形成作用示意图蛋白C个蛋白S1灭活Ila、1Xa、IXa1个ADP酶、E纤维蛋白溶解PGINOA11t-PA肝素样分子抗凝血酸Ⅲ凝血醇7凝血醇调节蛋白
内皮细胞抑制血栓形成作用示意图
(2).Prothrombotic propertiesDActivate exogenous coagulation processPromoting adhesion of plateletInhibitingfibrinolysis2.Functions of Platelets:DAdhesionand shapechangeSecretion (release reaction)Aggregation
① Activate exogenous coagulation process ② Promoting adhesion of platelet ③ Inhibiting fibrinolysis 2. Functions of Platelets: ① Adhesion and shape change ② Secretion (release reaction) ③ Aggregation (2). Prothrombotic properties