(A)HYDROLYSIS OF AN AMIDE BOND ● -N-H+ H tetrahedral water intermediate (B)TRANSITION-STATE ANALOG FOR AMIDE HYDROLYSIS HN HN NH NH O NO2 OH O analog amide Figure 3-47.Molecular Biology of the Cell,4th Edition
OH 6-0H R 0 R 0 →Products 0 08 Ester hydrolysis Transition state 06 R 0 R Analog (phosphonate) OH 8-0H H H-N H一】 →Products H NO NO Carbonate hydrolysis Transition state H 06 H-N H NO Box 8-3 Lehn Analog (phosphate)
Box 8-3 Lehn
(a)No enzyme Substrate Transition state Products (metal stick) (bent stick) (broken stick) Fig.8-5 Lehn
Fig. 8-5 Lehn
(b)Enzyme complementary to substrate Magnets Gancat → ES Fig.8-5 Lehn
Fig. 8-5 Lehn
(c)Enzyme complementary to transition state G neat Reaction coordinate Fig.8-5 Lehn
Fig. 8-5 Lehn