Chapter 9 Enzyme Specificity and Regulation Metabolie regulation is achteved throgh an exguisitely balonced interplay among enzymes
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9.1.Specificity Is the Result of Molecular Recognition "Induced Fit"and the Transition- State Intermediate
9.1 • Specificity Is the Result of Molecular Recognition “Induced Fit” and the TransitionState Intermediate
Active ste (a)Lock-and-key mocel Active site Transition state conformation (b)nduced俄moce
Substrate Active Key and lock site b ES complex Enzyme Substrate Induce fit ES complex Enzyme
Key and lock Induce fit
The induced conformational change in hexokinase M11.8 D-glucose (a)Before glucose binding (b)After glucose binding Induced fit is the main model for changes in the enzyme to fit the transition state and to bring functional side groups of the enzyme to the right location to help the catalysis
The induced conformational change in hexokinase M11.8 Induced fit is the main model for changes in the enzyme to fit the transition state and to bring functional side groups of the enzyme to the right location to help the catalysis